The angiotensin AT2 receptor: from a binding site to a novel therapeutic target
UM Steckelings, RE Widdop, ED Sturrock… - Pharmacological …, 2022 - ASPET
Discovered more than 30 years ago, the angiotensin AT2 receptor (AT2R) has evolved from
a binding site with unknown function to a firmly established major effector within the …
a binding site with unknown function to a firmly established major effector within the …
Molecular mechanisms of myocardial remodeling
B Swynghedauw - Physiological reviews, 1999 - journals.physiology.org
Swynghedauw, Bernard. Molecular Mechanisms of Myocardial Remodeling. Physiol. Rev.
79: 215–262, 1999.—“Remodeling” implies changes that result in rearrangement of …
79: 215–262, 1999.—“Remodeling” implies changes that result in rearrangement of …
[图书][B] Генетический паспорт–основа индивидуальной и предиктивной медицины
В Баранов - 2022 - books.google.com
В доступной форме в книге изложены основные события, произошедшие в
медицинской генетике и в молекулярной медицине после расшифровки генома …
медицинской генетике и в молекулярной медицине после расшифровки генома …
Recent progress in angiotensin II type 2 receptor research in the cardiovascular system
M Horiuchi, M Akishita, VJ Dzau - Hypertension, 1999 - Am Heart Assoc
Angiotensin II (Ang II) plays an important role in regulating cardiovascular hemodynamics
and structure. Multiple lines of evidence have suggested the existence of Ang II receptor …
and structure. Multiple lines of evidence have suggested the existence of Ang II receptor …
Pathophysiological role of angiotensin II type 2 receptor in cardiovascular and renal diseases
H Matsubara - Circulation research, 1998 - Am Heart Assoc
Since the discovery of nonpeptidic ligands, the receptors for angiotensin (Ang) II have been
classified into 2 subtypes (Ang II type 1 receptor [AT1-R] and Ang II type 2 receptor [AT2-R]) …
classified into 2 subtypes (Ang II type 1 receptor [AT1-R] and Ang II type 2 receptor [AT2-R]) …
Angiotensin II has multiple profibrotic effects in human cardiac fibroblasts
H Kawano, YS Do, Y Kawano, V Starnes, M Barr… - Circulation, 2000 - Am Heart Assoc
Background—Angiotensin II (Ang II) is implicated in cardiac remodeling and is increasingly
recognized for its profibrotic activity. Methods and Results—Because little is known about …
recognized for its profibrotic activity. Methods and Results—Because little is known about …
Localization and function of angiotensin AT1 receptors
AM Allen, J Zhuo… - American journal of …, 2000 - academic.oup.com
The distributions of angiotensin AT1 and AT2 receptors have been mapped by in vitro
autoradiography throughout most tissues of many mammals, including humans. In addition …
autoradiography throughout most tissues of many mammals, including humans. In addition …
ACE2 gene expression is up-regulated in the human failing heart
AB Goulter, MJ Goddard, JC Allen, KL Clark - BMC medicine, 2004 - Springer
Background ACE2 is a novel homologue of angiotensin converting enzyme (ACE). ACE2 is
highly expressed in human heart and animal data suggest that ACE2 is an essential …
highly expressed in human heart and animal data suggest that ACE2 is an essential …
The renin-angiotensin-aldosterone system: cardiorenal effects and implications for renal and cardiovascular disease states
UC Brewster, MA Perazella, JF Setaro - The American journal of the …, 2003 - Elsevier
The renin-angiotensin-aldosterone system (RAAS) plays an integral role in maintaining
vascular tone, optimal salt and water homeostasis, and cardiac function in humans …
vascular tone, optimal salt and water homeostasis, and cardiac function in humans …
Angiotensin II and the vascular phenotype in hypertension
Hypertension is associated with vascular changes characterised by remodelling, endothelial
dysfunction and hyperreactivity. Cellular processes underlying these perturbations include …
dysfunction and hyperreactivity. Cellular processes underlying these perturbations include …