This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Vascular cognitive impairment (VCI) or vascular dementia occurs as a result of brain
ischemia and represents the second most common type of dementia after Alzheimer's …

Sphingosine kinases (isoforms SK1 and SK2) catalyse the formation of a bioactive lipid,
sphingosine 1-phosphate (S1P). S1P is a well-established ligand of a family of five S1P …

Background: Cerebral small vessel disease (cSVD), a common risk factor for cognitive
impairment, involves unspecific arteriopathy characterized by hypertrophy and endothelial …

Resistance arteries and downstream arterioles in the peripheral microcirculation contribute
substantially to peripheral vascular resistance, control of blood pressure, the distribution of …

Atrial fibrillation (AF) and dementia are both frequent diseases with substantial
socioeconomic impact. While AF has been associated with cognitive dysfunction and …

Alzheimer disease (AD) is marked by profound neurodegeneration, neuroinflammation, and
cognitive decline. Pathologically, AD is characterized by the accumulation of extracellular …

Subarachnoid hemorrhage (SAH) is a devastating stroke subtype with a high rate of
mortality and morbidity. The poor clinical outcome can be attributed to the biphasic course of …

Heart failure—either with reduced or preserved ejection fraction (HFrEF/HFpEF)—is a
clinical syndrome of multifactorial and gender-dependent aetiology, indicating the …

Myocardial infarction (MI) occurs when coronary blood flow is decreased due to an
obstruction/occlusion of the vessels, leading to myocardial death and progression to heart …