Antibiotics have transformed modern medicine. They are essential for treating infectious
diseases and enable vital therapies and procedures. However, despite this success, their …

Antibacterial resistance is one of the greatest threats to human health. The development of
new therapeutics against bacterial pathogens has slowed drastically since the approvals of …

Resistance threatens to render antibiotics—which are essential for modern medicine—
ineffective, thus posing a threat to human health. The discovery of novel classes of …

Although antibiotics have been indispensable in the advancement of modern medicine,
there are downsides to their use. Growing resistance to broad-spectrum antibiotics is …

Monoclonal antibodies (mABs) are safe and effective proteins produced in laboratory that
may be used to target a single epitope of a highly conserved protein of a virus or a bacterial …

The type III secretion system (T3SS) is a virulence apparatus used by many Gram-negative
pathogenic bacteria to cause infections. Pathogens utilizing a T3SS are responsible for …

Acute and chronic lower airway disease still represent a major cause of morbidity and
mortality on a global scale. With the steady rise of multidrug-resistant respiratory pathogens …

Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen that causes high
morbidity and mortality in cystic fibrosis (CF) and immunocompromised patients, including …

Highlights•Technology advances have enhanced development of monoclonal antibodies for
infectious diseases.•Antibodies function through the collaboration between Fab and Fc …

Human infections caused by the opportunist pathogens Burkholderia cepacia complex and
Pseudomonas aeruginosa are of particular concern due to their severity, their multiple …