The intestinal tract faces numerous challenges that require several layers of defence. The
tight epithelium forms a physical barrier that is further protected by a mucus layer, which …

Human intestinal morphogenesis establishes 3D epithelial microarchitecture and spatially
organized crypt–villus characteristics. This unique structure is necessary to maintain …

Over the past decade, it has become exceedingly clear that the microbiome is a critical factor
in human health and disease and thus should be investigated to develop innovative …

Background The gut microbiome plays an important role in human health and disease.
Gnotobiotic animal and in vitro cell-based models provide some informative insights into …

Microphysiological systems (MPSs) are cellular models that replicate aspects of organ and
tissue functions in vitro. In contrast with conventional cell cultures, MPSs often provide …

Microfluidic lumen-based systems are microscale models that recapitulate the anatomy and
physiology of tubular organs. These technologies can mimic human pathophysiology and …

New drug discovery is under growing pressure to satisfy the demand from a wide range of
domains, especially from the pharmaceutical industry and healthcare services. Assessment …

Microfluidic technologies have been extensively investigated in recent years for developing
organ-on-a-chip-devices as robust in vitro models aiming to recapitulate organ 3D …

Simple Summary Although colorectal cancer is the third most common type of cancer, its
treatment strategies still have room for improvement, as current techniques carry risks that …

New types of protein sources will enter our diet in a near future, reinforcing the need for a
straightforward in vitro (cell‐based) screening model to test and predict the safety of these …