Cerebral cavernous malformations (CCMs) are vascular lesions that can occur sporadically
or as a consequence of inherited loss-of-function mutations, predominantly in the genes …

Ras and Rap proteins are closely related small GTPases. Whereas Ras is known for its role
in cell proliferation and survival, Rap1 is predominantly involved in cell adhesion and cell …

Cerebral cavernous malformations (CCM s) are vascular malformations located within the
central nervous system often resulting in cerebral hemorrhage. Pharmacological treatment is …

Cerebral cavernous malformations (CCM) are frequent vascular abnormalities caused by
mutations in one of the CCM genes. CCM1 (also known as KRIT1) stabilizes endothelial …

Over the past half century molecular biology has led to great advances in our understanding
of angio-and vasculogenesis and in the treatment of malformations resulting from these …

Normal brain homeostasis depends on the integrity of the blood–brain barrier that controls
the access of nutrients, humoral factors, and immune cells to the CNS. The blood–brain …

Rap proteins are Ras-like small GTP-binding proteins that amongst others are involved in
the control of cell–cell and cell–matrix adhesion. Several Rap guanine nucleotide exchange …

Loss-of-function mutations in genes encoding KRIT1 (also known as CCM1), CCM2 (also
known as OSM and malcavernin) or PDCD10 (also known as CCM3) cause cerebral …

The endothelial CCM complex regulates blood vessel stability and permeability. Loss-of-
function mutations in CCM genes are responsible for human cerebral cavernous …

Cerebral cavernous malformations (CCM) are manifested by microvascular lesions
characterized by leaky endothelial cells with minimal intervening parenchyma …