ATP-binding cassette (ABC) transporters mediate the ATP-driven translocation of structurally
and mechanistically distinct substrates against steep concentration gradients. Among the …

Although cancer is still one of the most significant global challenges facing public health, the
world still lacks complementary approaches that would significantly enhance the efficacy of …

Therapeutic resistance has been and remains to be the major challenge in developing
successful treatments for different cancers and therefore, understanding the underlying …

Chemotherapeutics are the mainstay treatment for metastatic breast cancers. However, the
chemotherapeutic failure caused by multidrug resistance (MDR) remains a pivotal obstacle …

Abstract Acyl-CoA synthetase-4 (ACSL4) is an enzyme implicated in estrogen receptor α
(ERα) negative regulation and hormone therapy resistance in breast cancer. In addition …

Severe forms of pulmonary arterial hypertension (PAH) are most frequently the
consequence of a lumen-obliterating angiopathy. One pathobiological model is that the …

Chronic infection by high-risk human papillomaviruses (HPV) and chronic inflammation are
factors associated with the onset and progression of several neoplasias, including cervical …

Solute carrier organic anion transporter family member 2A1 (SLCO2A1, also known as PGT,
OATP2A1, PHOAR2, or SLC21A2) is a plasma membrane transporter consisting of 12 …

Acquired resistance to doxorubicin is a major hurdle in triple-negative breast cancer (TNBC)
therapy, emphasizing the need to identify improved strategies. Apigenin and other …

Cytotoxic chemotherapy continues to be the main therapeutic option for patients with
metastatic breast cancer. Several studies have reported a significant association between …