Overflow metabolism is a common phenomenon observed at higher glycolytic flux in many
bacteria, yeast (known as Crabtree effect), and mammalian cells including cancer cells …

The independence of research is a key strategic issue of modern societies. Dealing with it
appropriately poses legal, economic, political, social and cultural problems for society, which …

Many cellular activities in bacteria are organized according to their growth rate. The notion
that ppGpp measures the cell's growth rate is well accepted in the field of bacterial …

Anaerobic microbial fermentations provide high product yields and are a cornerstone of
industrial bio-based processes. However, the need for redox balancing limits the array of …

Background Adenosine triphosphate (ATP) is the main energy carrier in living organisms,
critical for metabolism and essential physiological processes. In humans, abnormal …

Microbes may maximize the number of daughter cells per time or per amount of nutrients
consumed. These two strategies correspond, respectively, to the use of enzyme-efficient or …

Bacterial growth follows simple laws in constant conditions. However, bacteria in nature
often face fluctuating environments. We therefore ask whether there are growth laws that …

Root exudation increases the concentration of readily available carbon (C) compounds in its
immediate environment. This creates 'hotspots' of microbial activity characterized by …

The micro-aerophilic organisms and aerobes as well as yeast and higher organisms have
evolved to gain energy through respiration (via oxidative phosphorylation), thereby enabling …

Quantifying the contribution of individual molecular components to complex cellular
processes is a grand challenge in systems biology. Here we establish a general theoretical …