Cytotoxicity of snake venom enzymatic toxins: phospholipase A2 and l-amino acid oxidase

JJ Hiu, MKK Yap - Biochemical society transactions, 2020 - portlandpress.com
The phospholipase A2 (PLA2) and l-amino acid oxidase (LAAO) are two major enzymes
found in the venoms from most snake species. These enzymes have been structurally and …

Haemostatically active proteins in snake venoms

T Sajevic, A Leonardi, I Križaj - Toxicon, 2011 - Elsevier
Snake venom proteins that affect the haemostatic system can cause (a) lowering of blood
coagulability,(b) damage to blood vessels, resulting in bleeding,(c) secondary effects of …

Snake venom L‐amino acid oxidases: Trends in pharmacology and biochemistry

LFM Izidoro, JC Sobrinho, MM Mendes… - BioMed research …, 2014 - Wiley Online Library
L‐amino acid oxidases are enzymes found in several organisms, including venoms of
snakes, where they contribute to the toxicity of ophidian envenomation. Their toxicity is …

Bleeding and Thrombosis: Insights into Pathophysiology of Bothrops Venom-Related Hemostasis Disorders

S Larréché, JP Chippaux, L Chevillard… - International Journal of …, 2021 - mdpi.com
Toxins from Bothrops venoms targeting hemostasis are responsible for a broad range of
clinical and biological syndromes including local and systemic bleeding, incoagulability …

Past decade study of snake venom L-amino acid oxidase

C Guo, S Liu, Y Yao, Q Zhang, MZ Sun - Toxicon, 2012 - Elsevier
As one of the major protein (enzyme) components of snake venom (SV), l-amino acid
oxidase (LAAO) plays an important role in the toxicities and biological activities for SV …

Crosstalk of Inflammation and Coagulation in Bothrops Snakebite Envenoming: Endogenous Signaling Pathways and Pathophysiology

JS Cavalcante, DEG de Almeida… - International Journal of …, 2023 - mdpi.com
Snakebite envenoming represents a major health problem in tropical and subtropical
countries. Considering the elevated number of accidents and high morbidity and mortality …

[HTML][HTML] Snake venom L-amino acid oxidases: an overview on their antitumor effects

TR Costa, SM Burin, DL Menaldo… - Journal of Venomous …, 2014 - SciELO Brasil
The L-amino acid oxidases (LAAOs) constitute a major component of snake venoms and
have been widely studied due to their widespread presence and various effects, such as …

[HTML][HTML] Comparative analysis of newborn and adult Bothrops jararaca snake venoms

TC Antunes, KM Yamashita, KC Barbaro, M Saiki… - Toxicon, 2010 - Elsevier
Different clinical manifestations have been reported to occur in patients bitten by newborn
and adult Bothrops jararaca snakes. Herein, we studied the chemical composition and …

Oxidative stress induced by Pollonein-LAAO, a new L-amino acid oxidase from Bothrops moojeni venom, prompts prostate tumor spheroid cell death and impairs the …

L Polloni, TR Costa, LP Morais, BC Borges… - Cellular …, 2023 - Elsevier
Cancer cells produce abnormal levels of reactive oxygen species (ROS) that contribute to
promote their malignant phenotype. In this framework, we hypothesized that the change in …

Snake venom toxins: Potential anticancer therapeutics

BC Offor, LA Piater - Journal of Applied Toxicology, 2024 - Wiley Online Library
Snake venom contains a cocktail of compounds dominated by proteins and peptides, which
make up the toxin. The toxin components of snake venom attack several targets in the …