The multifaceted biology of PCSK9
NG Seidah, A Prat - Endocrine reviews, 2022 - academic.oup.com
This article reviews the discovery of PCSK9, its structure–function characteristics, and its
presently known and proposed novel biological functions. The major critical function of …
presently known and proposed novel biological functions. The major critical function of …
[HTML][HTML] The potential use of simvastatin for cancer treatment: A review
JA Duarte, ALB de Barros, EA Leite - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Statins, typically used to reduce lipid levels, have been rediscovered for exhibiting
anticancer activities. Among them, especially simvastatin may influence the proliferation …
anticancer activities. Among them, especially simvastatin may influence the proliferation …
PCSK9 promotes the progression and metastasis of colon cancer cells through regulation of EMT and PI3K/AKT signaling in tumor cells and phenotypic polarization of …
L Wang, S Li, H Luo, Q Lu, S Yu - Journal of Experimental & Clinical …, 2022 - Springer
Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) is the ninth member of
the proprotein convertase family that regulates lipoprotein homeostasis and altered PCSK9 …
the proprotein convertase family that regulates lipoprotein homeostasis and altered PCSK9 …
Beyond lipid-lowering: effects of statins on cardiovascular and cerebrovascular diseases and cancer
Y Morofuji, S Nakagawa, K Ujifuku, T Fujimoto… - Pharmaceuticals, 2022 - mdpi.com
The 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, also known
as statins, are administered as first-line therapy for hypercholesterolemia, both as primary …
as statins, are administered as first-line therapy for hypercholesterolemia, both as primary …
Cholesterol: An important actor on the cancer immune scene
H Halimi, S Farjadian - Frontiers in Immunology, 2022 - frontiersin.org
Based on the structural and signaling roles of cholesterol, which are necessary for immune
cell activity, high concentrations of cholesterol and its metabolites not only trigger malignant …
cell activity, high concentrations of cholesterol and its metabolites not only trigger malignant …
Finding new molecular targets of two copper (II)-hydrazone complexes on triple-negative breast cancer cells using mass-spectrometry-based quantitative proteomics
Breast cancer is the most common cancer in women, with a high incidence estimated to
reach 2.3 million by 2030. Triple-Negative Breast Cancer (TNBC) is the greatest invasive …
reach 2.3 million by 2030. Triple-Negative Breast Cancer (TNBC) is the greatest invasive …
Decreasing trend of blood lipid profile in type 2 diabetes: Not a promising change in HDL-C, a serial cross-sectional study
Background The prevalence of dyslipidemia in patients with type 2 diabetes (T2D) has been
reported to be relatively high. The current study aimed to investigate the trend of serum lipid …
reported to be relatively high. The current study aimed to investigate the trend of serum lipid …
Contribution of serum lipids and cholesterol cellular metabolism in lung cancer development and progression
P Hartmann, DI Trufa, K Hohenberger, P Tausche… - Scientific Reports, 2023 - nature.com
Neoplasms of the lungs are the leading cause of cancer incidence and mortality worldwide.
Although immunotherapy has increased the overall survival of patients with lung cancer …
Although immunotherapy has increased the overall survival of patients with lung cancer …
The evolving landscape of PCSK9 inhibition in cancer
PP Oza, K Kashfi - European journal of pharmacology, 2023 - Elsevier
Cancer is a disease with a significant global burden in terms of premature mortality, loss of
productivity, healthcare expenditures, and impact on mental health. Recent decades have …
productivity, healthcare expenditures, and impact on mental health. Recent decades have …
Obesity programs macrophages to support cancer progression
Obesity induces multifactorial effects such as dyslipidemia, insulin resistance, and arterial
hypertension that influence the progression of many diseases. Obesity is associated with an …
hypertension that influence the progression of many diseases. Obesity is associated with an …