Accumulating evidence indicates that intratumoral heterogeneity contributes to the
development of resistance to anticancer therapeutics. Fibroblasts, which are components of …

Cancer cell migration and invasion are integral components of metastatic disease, which is
the major cause of death in cancer patients. Cancer cells can disseminate and migrate via …

Background Nucleotide metabolism is a critical pathway that generates purine and
pyrimidine molecules for DNA replication, RNA synthesis, and cellular bioenergetics …

Hypoxia-induced alternative splicing is a potent driving force in tumour pathogenesis and
progression. In this review, we update currents concepts of hypoxia-induced alternative …

Long-term exposure to crystalline silica particles leads to silicosis characterized by
persistent inflammation and progressive fibrosis in the lung. So far, there is no specific …

Melanomas can have multiple coexisting cell states, including proliferative (PRO) versus
invasive (INV) subpopulations that represent a" go or grow" trade-off; however, how these …

The interaction between circulating tumor cells and platelets is a key factor in cancer
metastasis. These interactions, driven by a variety of receptors, support circulating tumor …

Genetic and phenotypic heterogeneity contribute to the generation of diverse tumor cell
populations, thus enhancing cancer aggressiveness and therapy resistance. Compared to …

Epithelial–mesenchymal transitions (EMTs) generate hybrid phenotypes with an enhanced
ability to adapt to diverse microenvironments encountered during the metastatic spread …

Simple Summary Dielectrophoresis (DEP) is a label-free cell manipulation technique based
on electrical differences that can be applied to liquid biopsies in the context of cancer …