X chromosome inactivation and genomic imprinting are classic epigenetic processes that
cause disease when not appropriately regulated in mammals. Whereas X chromosome …

Mammalian females have two X chromosomes and males have only one. This has led to the
evolution of special mechanisms of dosage compensation. The inactivation of one X …

Preimplantation development is a period of dynamic epigenetic change that begins with
remodeling of egg and sperm genomes, and ends with implantation. During this time …

X-chromosome inactivation is widely believed to be random in early female development
and to result in a mosaic distribution of cells, approximately half with the paternally derived X …

X inactivation is the silencing one of the two X chromosomes in XX female mammals.
Initiation of this process during early development is controlled by the X-inactivation centre …

▪ Abstract Mammalian X chromosome inactivation is one of the most striking examples of
epigenetic gene regulation. Early in development one of the pair of∼ 160-Mb X …

Currently, behavioral development is thought to result from the interplay among genetic
inheritance, congenital characteristics, cultural contexts, and parental practices as they …

Allelic expression differences contribute to phenotypic variation. In X chromosome
inactivation (XCI), unfavorable XCI ratios promote X-linked disease penetrance in females …

We have developed a sensitized screen to identify genes involved in gene silencing, using
random N-ethyl-N-nitrosourea mutagenesis on mice carrying a variegating GFP transgene …

Germ cells undergo epigenetic modifications as they develop, which suggests that they may
be ideal donors for nuclear transfer (cloning). In this study, nuclei from confirmed embryonic …