This article reviews the molecular structure, expression pattern, physiological function,
pathological roles and molecular mechanisms of Twist1 in development, genetic disease …

The transcriptome of every cell is orchestrated by the complex network of interaction
between transcription factors (TFs) and their binding sites on DNA. Disruption of this network …

During pregnancy, progesterone inhibits the growth-promoting actions of estrogen in the
uterus. However, the mechanism for this is not clear. The attenuation of estrogen-mediated …

The scleraxis (Scx) gene, encoding a bHLH transcription factor, is expressed in the
progenitors and cells of all tendon tissues. To determine Scx function, we produced a mutant …

Abstract mRNA expression profiling has suggested the existence of multiple glioblastoma
subclasses, but their number and characteristics vary among studies and the etiology …

Autosomal dominant mutations in the gene encoding the basic helix-loop-helix transcription
factor Twist1 are associated with limb and craniofacial defects in humans with Saethre …

A finite number of transcription factors constitute a combinatorial code that orchestrates
cardiac development and the specification and differentiation of myocytes. Many, if not all of …

The lower jaw skeleton is derived from cephalic neural crest (CNC) cells that reside in the
mandibular region of the first pharyngeal arch. Endothelin-A receptor (Ednra) signaling in …

Abstract The basic Helix‐Loop‐Helix (bHLH) transcription factors Hand1 and Hand2 play
critical roles in the development of multiple organ systems during embryogenesis. The …

BACKGROUND & AIMS: Enteric neurons have been reported to be increased in inflamed
regions of the bowel in patients with inflammatory bowel disease or intestinal …