The blood-brain barrier (BBB) constitutes a microvascular network responsible for excluding
most drugs from the brain. Treatment of brain tumors is limited by the impermeability of the …

The immune system has to cope with a wide range of irregularly shaped pathogens that can
actively move (eg, by flagella) and also dynamically remodel their shape (eg, transition from …

Nanomaterial-based drug delivery systems (NBDDS) are widely used to improve the safety
and therapeutic efficacy of encapsulated drugs due to their unique physicochemical and …

Nanoparticles (NPs), owing to their ultrasmall size, have been extensively researched for
potential applications in biomedicine. During their delivery and functionalization within the …

Introduction A major challenge in treating central nervous system (CNS) disorders is to
achieve adequate drug delivery across the blood–brain barrier (BBB). Receptor-mediated …

Alzheimer's disease (AD), the most common form of dementia, is a progressive and
multifactorial neurodegenerative disorder whose primary causes are mostly unknown. Due …

Sesamol is a lignan of sesame seeds and a natural phenolic molecule that has emerged as
a useful medical agent. Sesamol is a non-toxic phytoconstituent, which exerts certain …

The deposition of β-amyloid (Aβ) plaques in the parenchymal and cortical regions of the
brain of Alzheimer's disease (AD) patients is considered the foremost pathological hallmark …

In recent years, unique physicochemical properties of amphiphilic block copolymers have
been utilized to design the polymeric micelles for brain-specific delivery of drugs, proteins …

The cell membrane serves as a barrier against the free entry of foreign substances into the
cell. Limited by factors such as solubility and targeting, it is difficult for some drugs to pass …