Developing greener synthesis processes is an inescapable necessity to transform the
industrial landscape, mainly in the pharmaceutical sector, into a long-term, sustainable …

The market of biomolecules with therapeutic scopes, including peptides, is continuously
expanding. The interest towards this class of pharmaceuticals is stimulated by the broad …

Small molecule therapeutics represent the majority of the FDA-approved drugs. Yet, many
attractive targets are poorly tractable by small molecules, generating a need for new …

Continuous production delivers higher productivity and better quality than traditional batch-
wise approaches. It intensifies production lowering capital cost and enables better control …

Hemp and cannabis industry is undergoing a renewed interest due to legalization of
marijuana (a topic that all countries are discussing, especially in recent years) and the …

Single-column (batch) preparative chromatography is the technique of choice for purification
of biotherapeutics but it is often characterized by an intrinsic limitation in terms of yield-purity …

The investigation of new green biogenic pyrrolidinones as alternative solvents to N, N-
dimethylformamide (DMF) for solid phase peptide synthesis (SPPS) led to the identification …

This work reports about a screening of four adsorbents with different polarity employed for
the separation of the main phytocannabinoids contained in Cannabis sativa L., under …

The multicolumn counter-current solvent gradient purification (MCSGP) method has proven
effective in addressing the issue of elution profile overlap for difficult-to-separate proteins …

Preparative liquid chromatography in reversed phase conditions (RPLC) is the most
common approach adopted in the downstream processing for the purification of therapeutic …