Resistance to chemo-and radiotherapy is a common event among cancer patients and a
reason why new cancer therapies and therapeutic strategies need to be in continuous …

In the last two decades, an increasing amount of studies have investigated the use of
components based on carbon-(nano) materials in the engineering of neural interfaces, to …

Neutrophil (PMN) infiltration of the intestinal mucosa is a hallmark of tissue injury associated
with inflammatory bowel diseases (IBDs). The pathological effects of PMNs are largely …

DNA damage is correlated with and may drive the ageing process. Neurons in the brain are
postmitotic and are excluded from many forms of DNA repair; therefore, neurons are …

The maintenance of genome integrity is essential for any organism survival and for the
inheritance of traits to offspring. To the purpose, cells have developed a complex DNA repair …

Innate and acquired resistance towards the conventional therapeutic regimen imposes a
significant challenge for the successful management of cancer for decades. In patients with …

Acute myeloid leukemias (AML) are characterized by mutations of tumor suppressor and
oncogenes, involving distinct genes in adults and children. While certain mutations have …

Ovarian cancer is the leading cause of gynecological cancer-related death. Drug resistance
is the bottleneck in ovarian cancer treatment. The increasing use of novel drugs in clinical …

Simple Summary Cells respond to genotoxic stress through complex protein pathways
called DNA damage response (DDR). These mechanisms ensure the preservation of …

Purpose: MicroRNAs (miRNA) play a paramount role in growth, differentiation, proliferation
and cell death by suppressing one or more target genes. However, their interaction with …