Neurodegenerative diseases are commonly associated with the formation of aberrant
protein aggregates within the brain, and ultrastructural analyses have revealed that the …

Tauopathies are neurodegenerative diseases characterized by abnormal conformational
changes in tau protein. Early hyperphosphorylation-induced conformational changes are …

Tau seed amplification assays (SAAs) directly measure the seeding activity of tau and would
therefore be ideal biomarkers for clinical trials targeting seeding-competent tau in …

Tau aggregates are present in multiple neurodegenerative diseases known as
“tauopathies,” including Alzheimer's disease (AD), Pick's disease (PiD), progressive …

Tauopathies are a class of neurodegenerative diseases correlated with the presence of
pathological Tau fibrils as a diagnostic marker. The microtubule-binding repeat region of …

Alzheimer's disease (AD) is characterized by a long preclinical phase. Although late-stage
AD/dementia may be robustly differentiated from cognitively normal individuals by means of …

Alzheimer's disease (AD) is one of the leading causes of death worldwide, with no definitive
diagnosis or known cure. The aggregation of Tau protein into neurofibrillary tangles (NFTs) …

Tau aggregation associates with multiple neurodegenerative diseases including Alzheimer's
disease and rare tauopathies such as Pick's disease, progressive supranuclear palsy, and …

Background and objective There is mounting evidence to suggest that the gut-brain axis is
involved in the development of Parkinson's disease (PD). In this regard, the enteroendocrine …

Parkinson's disease (PD) is the second most common neurodegenerative disease, affecting
the elderly population worldwide. In PD, the misfolding of α-synuclein (α-syn) results in the …