One of the early success stories of computational systems biology was the work done on cell-
cycle regulation. The earliest mathematical descriptions of cell-cycle control evolved into …

The cell cycle in pluripotent stem cells is notable for the brevity of the G1 phase, permitting
rapid proliferation and reducing the duration of differentiation signal sensitivity associated …

Dynamical modelling is at the core of the systems biology paradigm. However, the
development of comprehensive quantitative models is complicated by the daunting …

Poorly differentiated colorectal cancers (CRCs) are more aggressive and lack targeted
therapies. We and others previously reported the predominant role of tumor-suppressor …

Epigenetic silencing of secreted wingless-type (Wnt) antagonists through hypermethylation
is associated with tobacco smoking and with invasive bladder cancer. The secreted Wnt …

A wide range of cellular processes require molecular regulatory pathways to convert a
graded signal into a discrete response. One prevalent switching mechanism relies on the …

Background Triple negative breast cancer (TNBC) has the worst prognosis of the any breast
cancer subtype, and the efficient therapeutical treatment is extremely limited. Antenoron …

After DNA damage, cells must decide between different fates including growth arrest, DNA
repair, and apoptosis. Both p53 and E2F1 are transcription factors involved in the decision …

OBJECTIVE: Increasing evidence demonstrated that long non-coding RNA (lncRNA) played
a vital role in human tumorigenesis and progression, including colorectal cancer (CRC) …

The sympathetic division of the autonomic nervous system includes a variety of cells
including neurons, endocrine cells and glial cells. A recent study (Furlan et al. 2017) has …