Succinate is an important metabolite at the cross-road of several metabolic pathways, also
involved in the formation and elimination of reactive oxygen species. However, it is …

Assessing mitochondrial dysfunction requires definition of the dysfunction to be investigated.
Usually, it is the ability of the mitochondria to make ATP appropriately in response to energy …

Emerging evidence indicates that cancer is primarily a metabolic disease involving
disturbances in energy production through respiration and fermentation. The genomic …

Background The rate at which cells acidify the extracellular medium is frequently used to
report glycolytic rate, with the implicit assumption that conversion of uncharged glucose or …

The term mitochondrial permeability transition (MPT) is commonly used to indicate an abrupt
increase in the permeability of the inner mitochondrial membrane to low molecular weight …

Neurodegenerative diseases are a spectrum of chronic, debilitating disorders characterised
by the progressive degeneration and death of neurons. Mitochondrial dysfunction has been …

Key points• Within cells, mitochondria oxidize carbohydrates, and fatty and amino acids to
use the released energy to form ATP, and in the process, they also generate reactive oxygen …

Little progress has been made in the long-term management of glioblastoma multiforme
(GBM), considered among the most lethal of brain cancers. Cytotoxic chemotherapy …

Adenine nucleotide translocase (ANT), a mitochondrial protein that facilitates the exchange
of ADP and ATP across the mitochondrial inner membrane, plays an essential role in …

Glioblastoma multiforme (GBM) is the most common and malignant of the primary adult brain
cancers. Ultrastructural and biochemical evidence shows that GBM cells exhibit …