Altered gene expression is a characteristic feature of many disease states such as
tumorigenesis, and in most cancers, it facilitates cancer cell survival and adaptation …

The RNA‐binding protein HuR (human antigen R) associates with numerous transcripts,
coding and noncoding, and controls their splicing, localization, stability, and translation …

Mutations in fused in sarcoma (FUS) are a cause of familial amyotrophic lateral sclerosis
(fALS). Patients carrying point mutations in the C‐terminus of FUS show neuronal …

Eukaryotic cells express a large variety of RNA binding proteins (RBPs), with diverse
affinities and specificities towards target RNAs. These proteins play a crucial role in almost …

Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is a member of the hnRNP family
of conserved proteins that is involved in RNA transcription, pre-mRNA splicing, mRNA …

Proteins in the karyopherin-β family mediate the majority of macromolecular transport
between the nucleus and the cytoplasm. Eleven of the 19 known human karyopherin-βs and …

The cytoplasmic events that control mammalian gene expression, primarily mRNA stability
and translation, potently influence the cellular response to internal and external signals. The …

Overexpressed in colon carcinoma-1 (OCC-1) is one of the earliest annotated long
noncoding RNAs (lncRNAs) in colorectal cancer (CRC); however, its function remains …

Cancer‐related gene expression programs are strongly influenced by posttranscriptional
mechanisms. The RNA‐binding protein HuR is highly abundant in many cancers. Numerous …

Karyopherinβ (Kapβ) proteins bind nuclear localization and export signals (NLSs and NESs)
to mediate nucleocytoplasmic trafficking, a process regulated by Ran GTPase through its …