BACKGROUND Chromatin is the essential medium through which transcription factors,
signaling pathways, and other cues alter gene activity and cellular phenotypes. It assumes …

Nutrigenomics studies how environmental factors, such as food intake and lifestyle,
influence the expression of the genome. Vitamin D3 represents a master example of …

Fibrotic disease is caused by the continuous deposition of extracellular matrix by persistently
activated fibroblasts (also known as myofibroblasts), even after the resolution of the injury …

Shoot regeneration is mediated by the sequential action of two phytohormones, auxin and
cytokinin. However, the chromatin regulatory landscapes underlying this dynamic response …

Nutrigenomics attempts to characterize and integrate the relation between dietary molecules
and gene expression on a genome-wide level. One of the biologically active nutritional …

Detection of DNA methylation in the genome has been possible for decades; however, the
ability to deliberately and specifically manipulate local DNA methylation states in the …

DNA methylation is a major epigenetic modification of vertebrate genomes that is mostly
associated with transcriptional repression. During embryogenesis, DNA methylation …

Embryonic genetic programs are reactivated in response to various types of tissue damage,
providing cell plasticity for tissue regeneration or disease progression. In acute conditions …

Histones shape chromatin structure and the epigenetic landscape. H1, the most diverse
histone in the human genome, has 11 variants. Due to the high structural similarity between …

Two waves of DNA methylation reprogramming occur during mammalian embryogenesis;
during preimplantation development and during primordial germ cell (PGC) formation …