Solid tumors have a unique tumor microenvironment (TME), which includes hypoxia, low
acidity, and high hydrogen peroxide and glutathione (GSH) levels, among others. These …

Colorectal cancer (CRC) is a major cause of cancer mortality worldwide, however, the
molecular mechanisms underlying the pathogenesis of CRC remain largely unclear. Recent …

Background The resistance to PD-1/PD-L1 inhibitors for the treatment of melanoma have
prompted investigators to implement novel clinical trials which combine immunotherapy with …

Aim Previous studies have reported that circular RNA (circRNA) is associated with the
pathogenesis of CRC. This study was designed to reveal the mechanism of circ-ring finger …

Abstract Microcystins-LR (MC-LR) acts as a possible carcinogen for humans and causes a
serious risk to public environmental health. The current study aimed to evaluate the …

The present study aimed to identify the therapeutic role of the forkhead box M1 (FOXM1)‑
associated pathway in triple‑negative breast cancer (TNBC). Using a Cancer Landscapes …

Aims: Due to a large number of identified hub-genes encoding key molecular regulators,
which are involved in signal transduction and metabolic pathways in cancers, it is relevant to …

Cyclooxygenase-2 (COX2) mRNA represents a key biomarker for identifying subjects with
colorectal cancer (CRC), while there is still no rapid and sensitive detection method for …

Tanshinone IIA (TSN) exhibits a variety of anticancer effects. However, whether it inhibits
gastric cancer (GC) cell proliferation and migration and the mechanism remain unclear. In …

Graphs can model complicated interactions between entities, which naturally emerge in
many important applications. These applications can often be cast into standard graph …