The nature of immune responses to urinary tract infections

SN Abraham, Y Miao - Nature Reviews Immunology, 2015 - nature.com
The urinary tract is constantly exposed to microorganisms that inhabit the gastrointestinal
tract, but generally the urinary tract resists infection by gut microorganisms. This resistance …

The immune response to infection in the bladder

L Lacerda Mariano, MA Ingersoll - Nature Reviews Urology, 2020 - nature.com
The bladder is continuously protected by passive defences such as a mucus layer,
antimicrobial peptides and secretory immunoglobulins; however, these defences are …

Longitudinal multi-omics analyses link gut microbiome dysbiosis with recurrent urinary tract infections in women

CJ Worby, HL Schreiber IV, TJ Straub, LR van Dijk… - Nature …, 2022 - nature.com
Recurrent urinary tract infections (rUTIs) are a major health burden worldwide, with history of
infection being a significant risk factor. While the gut is a known reservoir for uropathogenic …

NKp46 receptor-mediated interferon-γ production by natural killer cells increases fibronectin 1 to alter tumor architecture and control metastasis

A Glasner, A Levi, J Enk, B Isaacson, S Viukov… - Immunity, 2018 - cell.com
Natural killer (NK) cells are innate lymphoid cells, and their presence within human tumors
correlates with better prognosis. However, the mechanisms by which NK cells control tumors …

Virulence factors of uropathogenic E. coli and their interaction with the host

P Lüthje, A Brauner - Advances in microbial physiology, 2014 - Elsevier
Urinary tract infections (UTIs) belong to the most common infectious diseases worldwide.
The most frequently isolated pathogen from uncomplicated UTIs is Escherichia coli. To …

Immunomodulation therapy offers new molecular strategies to treat UTI

D Butler, I Ambite, MLY Wan, TH Tran, B Wullt… - Nature Reviews …, 2022 - nature.com
Innovative solutions are needed for the treatment of bacterial infections, and a range of
antibacterial molecules have been explored as alternatives to antibiotics. A different …

Innate immunity and urinary tract infection

C Ching, L Schwartz, JD Spencer, B Becknell - Pediatric nephrology, 2020 - Springer
Urinary tract infections are a severe public health problem. The emergence and spread of
antimicrobial resistance among uropathogens threaten to further compromise the quality of …

NK cell recognition of Candida glabrata through binding of NKp46 and NCR1 to fungal ligands Epa1, Epa6, and Epa7

A Vitenshtein, Y Charpak-Amikam, R Yamin… - Cell host & …, 2016 - cell.com
Natural killer (NK) cells form an important arm of the innate immune system and function to
combat a wide range of invading pathogens, ranging from viruses to bacteria. However, the …

Revealing leukocyte populations in human peri-implantitis and periodontitis using flow cytometry

O Ginesin, Y Mayer, E Gabay, D Rotenberg… - Clinical Oral …, 2023 - Springer
Objective To identify, quantify, and characterize leukocyte populations in PI and periodontitis
using flow cytometry. Methods Fresh biopsies from human PI and periodontitis lesions were …

Zika virus escapes NK cell detection by upregulating major histocompatibility complex class I molecules

A Glasner, E Oiknine-Djian, Y Weisblum… - Journal of …, 2017 - Am Soc Microbiol
ABSTRACT NK cells are innate lymphocytes that participate in many immune processes
encompassing cancer, bacterial and fungal infection, autoimmunity, and even pregnancy …