Complex biological systems and cellular networks may underlie most genotype to
phenotype relationships. Here, we review basic concepts in network biology, discussing …

A central goal of systems biology is to elucidate the structural and functional architecture of
the cell. To this end, large and complex networks of molecular interactions are being rapidly …

This book deals with the analysis of the structure of complex networks by combining results
from graph theory, physics, and pattern recognition. The book is divided into two parts. 11 …

Coupled biological and chemical systems, neural networks, social interacting species, the
Internet and the World Wide Web, are only a few examples of systems composed by a large …

A key aim of postgenomic biomedical research is to systematically catalogue all molecules
and their interactions within a living cell. There is a clear need to understand how these …

From the Internet to networks of friendship, disease transmission, and even terrorism, the
concept--and the reality--of networks has come to pervade modern society. But what exactly …

Protein-protein interaction maps provide a valuable framework for a better understanding of
the functional organization of the proteome. To detect interacting pairs of human proteins …

The local structure of unweighted networks can be characterized by the number of times a
subgraph appears in the network. The clustering coefficient, reflecting the local configuration …

A cell's behavior is a consequence of the complex interactions between its numerous
constituents, such as DNA, RNA, proteins and small molecules. Cells use signaling …

Motivation: Analogous to biological sequence comparison, comparing cellular networks is
an important problem that could provide insight into biological understanding and …