TBI is a leading cause of death and disability in young people and older adults worldwide.
There is no gold standard treatment for TBI besides surgical interventions and symptomatic …

This review explores the complex challenges and advancements in the treatment of
traumatic brain injury (TBI) and spinal cord injury (SCI). Traumatic injuries to the central …

Drug discovery for central nervous system (CNS) targets is a high stakes process with
estimated success rates below ten percent. Dose scaling, penetration through the blood …

Methods The AAST Critical Care Committee chose antibiotic management in the intensive
care unit (ICU) as a clinically relevant topic for review. This document is one of a three-part …

Introduction Traumatic brain injury (TBI) is associated with health problems across multiple
domains and TBI patients are reported to have high rates of medication use. However, prior …

Trauma is a complex disease, and the use of antibiotic prophylaxis (AP) in trauma patients is
common practice. However, considering the increasing rates of antibiotic resistance, AP use …

Introduction Low-velocity penetrating brain injury (LVPBI) is a class of brain injury where a
foreign object violates the skull and damages the brain. Such injuries are rare and …

Trauma is a complex disease, and the use of antibiotic prophylaxis (AP) in trauma patients is
common practice. However, considering the increasing rates of antibiotic resistance, AP use …

Context Penetrating craniocerebral injury associated with depressed skull fracture is an
infrequent yet timely neurosurgical emergency. Such injury frequently occurs in the frontal …

Hypothermia in a trauma patient has been associated with increased morbidity and mortality
and is more frequently seen in those sustaining traumatic brain injuries (TBIs). Acidosis is an …