Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally
regulate each other, are among the well-known cancer hallmarks. Recent evidence …

Epimutations, such as the hypermethylation and epigenetic silencing of tumor suppressor
genes, play a role in the etiology of human cancers. In contrast to DNA mutations, which are …

Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment
from the point of view of medicinal chemistry and drug design, focusing on the mechanism of …

DNA methylation regulates gene expression in normal and malignant cells. The possibility to
reactivate epigenetically silenced genes has generated considerable interest in the …

This review presents the different human DNA methyltransferases (DNMTs), their biological
roles, their mechanisms of action and their role in cancer. The description of assays for …

Advances in bioinformatics and protein modeling algorithms, in addition to the enormous
increase in experimental protein structure information, have aided in the generation of …

It has been previously demonstrated that genistein exhibits anticancer activity against breast
cancer. However, the precise mechanisms underlying the anticancer effect of genistein, in …

Virtual screening is increasingly being used in drug discovery programs with a growing
number of successful applications. Experimental methodologies developed to speed up the …

A series of Δ2-isoxazoline constrained analogues of procaine/procainamide (7a–k and 8a–
k) were prepared and their inhibitory activity against DNA methyltransferase 1 (DNMT1) was …

Enzymes involved in the epigenetic regulation of the genome represent promising starting
points for therapeutic intervention by small molecules, and DNA methyltransferases (DNMT) …