Targeting molecules to medicine with mTOR, autophagy and neurodegenerative disorders

K Maiese - British journal of clinical pharmacology, 2016 - Wiley Online Library
Neurodegenerative disorders are significantly increasing in incidence as the age of the
global population continues to climb with improved life expectancy. At present, more than 30 …

[HTML][HTML] Regeneration in the nervous system with erythropoietin

K Maiese - Frontiers in bioscience (Landmark edition), 2016 - ncbi.nlm.nih.gov
Globally, greater than 30 million individuals are afflicted with disorders of the nervous
system accompanied by tens of thousands of new cases annually with limited, if any …

[HTML][HTML] E2F1 Expression and apoptosis initiation in crayfish and rat peripheral neurons and glial cells after axonal injury

V Dzreyan, M Eid, S Rodkin, M Pitinova… - International Journal of …, 2022 - mdpi.com
Neurotrauma is among the main causes of human disability and mortality. The transcription
factor E2F1 is one of the key proteins that determine the fate of cells. The involvement of …

The localization of p53 in the crayfish mechanoreceptor neurons and its role in axotomy-induced death of satellite glial cells remote from the axon transection site

S Rodkin, A Khaitin, M Pitinova, V Dzreyan… - Journal of Molecular …, 2020 - Springer
Neuron and glia death after axon transection is regulated by various signaling proteins.
Protein p53 is a key regulator of diverse cell functions including stress response, DNA …

[HTML][HTML] A review of the actions of Nitric Oxide in development and neuronal function in major invertebrate model systems

NJD Wright - AIMS neuroscience, 2019 - ncbi.nlm.nih.gov
Ever since the late-eighties when endothelium-derived relaxing factor was found to be the
gas nitric oxide, endogenous nitric oxide production has been observed in virtually all …

The role of p53-dependent signaling pathways in survival and death of neurons and glial cells after peripheral nerve injury

SV Rodkin, VA Dzreyan, SV Demyanenko… - … ), Supplement Series A …, 2021 - Springer
Neurotrauma is one of the main causes of people's disability and death. However, the
mechanisms that mediate the survival and death of cells of the peripheral nervous system …

Ca2+ mediates axotomy-induced necrosis and apoptosis of satellite glial cells remote from the transection site in the isolated crayfish mechanoreceptor

A Khaitin, M Rudkovskii, A Uzdensky - Molecular and Cellular …, 2018 - Elsevier
Severe nerve injury such as axotomy induces neuron degeneration and death of
surrounding glial cells. Using a crayfish stretch receptor that consists of a single …

[HTML][HTML] Immediate release of gastrin-releasing peptide mediates delayed radiation-induced pulmonary fibrosis

RM Tighe, K Heck, E Soderblom, S Zhou… - The American Journal of …, 2019 - Elsevier
Radiation–induced pulmonary fibrosis (RTPF) is a progressive, serious condition in many
subjects treated for thoracic malignancies or after accidental nuclear exposure. No …

The effect of axotomy on firing and ultrastructure of the crayfish mechanoreceptor neurons and satellite glial cells

MV Rudkovskii, AG Fedorenko, AM Khaitin… - Molecular and Cellular …, 2020 - Elsevier
Neurotrauma is among main causes of human disability and death. We studied effects of
axotomy on ultrastructure and neuronal activity of a simple model object–an isolated crayfish …

Involvement of MAPK, Akt/GSK-3β and AMPK/mTOR signaling pathways in protection of remote glial cells from axotomy-induced necrosis and apoptosis in the …

EV Berezhnaya, MY Bibov, MA Komandirov… - Molecular and Cellular …, 2017 - Elsevier
Severe mechanical nerve injury such as axotomy can lead to neuron degeneration and
death of surrounding glial cells. We showed that axotomy not only mechanically injures glial …