Since the first description in 1989 of CD4‐Fc‐fusion antagonists that inhibit human immune
deficiency virus entry into T cells, Fc‐fusion proteins have been intensely investigated for …

Progressive insulin secretory defects, due to either functional abnormalities of the pancreatic
β-cells or a reduction in β-cell mass, are the cornerstone of type 2 diabetes. Incretin-based …

γ-Aminobutyric acid (GABA) exerts protective and regenerative effects on mouse islet β-
cells. However, in humans it is unknown whether it can increase β-cell mass and improve …

Peptide–Fc fusion proteins (or peptibodies) are chimeric proteins generated by fusing a
biologically active peptide with the Fc-domain of immunoglobulin G. In this review, we …

Glucagon-like peptide 1 (GLP-1) improves insulin resistance of adipose tissue in obese
humans. However, the mechanism of this effect is unclear. Perturbation of endoplasmic …

The global pandemic of obesity is increasing. Inappropriate food intake relative to energy
expenditure results in increased adiposity. These factors are partly regulated by signals …

Glucagon like peptide 1 (GLP-1), a blood glucose homeostasis modulating incretin, has
been proposed for the treatment of type 2 diabetes mellitus (T2DM). However, native GLP-1 …

Twelve novel dicoumarol glucagon-like peptide 1 (GLP-1) conjugates were designed,
synthesized, and tested for biological activity. All derivatives retained receptor activation …

γ-aminobutyric acid (GABA) or glucagon-like peptide-1 based drugs, such as sitagliptin (a
dipeptidyl peptidase-4 inhibitor), were shown to induce beta cell regenerative effects in …

Simple plasmid DNA injection is a safe and feasible gene transfer method, but it confers low
transfection efficiency and transgene expression. This non-viral gene transfer method is …