Vitamin D and systems biology
The biological actions of the vitamin D receptor (VDR) have been investigated intensively for
over 100 years and has led to the identification of significant insights into the repertoire of its …
over 100 years and has led to the identification of significant insights into the repertoire of its …
Human regulatory T cells: understanding the role of tregs in select autoimmune skin diseases and post-transplant nonmelanoma skin cancers
NC Oparaugo, K Ouyang, NPN Nguyen… - International journal of …, 2023 - mdpi.com
Regulatory T cells (Tregs) play an important role in maintaining immune tolerance and
homeostasis by modulating how the immune system is activated. Several studies have …
homeostasis by modulating how the immune system is activated. Several studies have …
Multi-ancestry genome-wide meta-analysis identifies novel basal cell carcinoma loci and shared genetic effects with squamous cell carcinoma
H Choquet, C Jiang, J Yin, Y Kim, TJ Hoffmann… - Communications …, 2024 - nature.com
Basal cell carcinoma (BCC) is one of the most common malignancies worldwide, yet its
genetic determinants are incompletely defined. We perform a European ancestry genome …
genetic determinants are incompletely defined. We perform a European ancestry genome …
Activin A–mediated polarization of cancer-associated fibroblasts and macrophages confers resistance to checkpoint immunotherapy in skin cancer
C Pich-Bavastro, L Yerly, J Di Domizio… - Clinical Cancer …, 2023 - AACR
Purpose: Cemiplimab is approved for the treatment of locally advanced basal cell
carcinomas (BCC), although with mitigated results. We sought to interrogate the cellular and …
carcinomas (BCC), although with mitigated results. We sought to interrogate the cellular and …
Codimension-one and codimension-two bifurcations in a new discrete chaotic map based on gene regulatory network model
M Liu, F Meng, D Hu - Nonlinear Dynamics, 2022 - Springer
In this paper, the stability and bifurcations of a new discrete chaotic map based on gene
regulatory network are studied. Firstly, the existence and stability conditions of the fixed …
regulatory network are studied. Firstly, the existence and stability conditions of the fixed …
[HTML][HTML] Oral and non-oral lichen planus show genetic heterogeneity and differential risk for autoimmune disease and oral cancer
MP Reeve, M Vehviläinen, S Luo, J Ritari… - The American Journal of …, 2024 - cell.com
Lichen planus (LP) is a T-cell-mediated inflammatory disease affecting squamous epithelia
in many parts of the body, most often the skin and oral mucosa. Cutaneous LP is usually …
in many parts of the body, most often the skin and oral mucosa. Cutaneous LP is usually …
A comprehensive comparison of multilocus association methods with summary statistics in genome-wide association studies
Z Shao, T Wang, J Qiao, Y Zhang, S Huang, P Zeng - BMC bioinformatics, 2022 - Springer
Background Multilocus analysis on a set of single nucleotide polymorphisms (SNPs) pre-
assigned within a gene constitutes a valuable complement to single-marker analysis by …
assigned within a gene constitutes a valuable complement to single-marker analysis by …
Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysis
J Yarmolinsky, JW Robinson, D Mariosa, V Karhunen… - …, 2024 - thelancet.com
Background Tumour-promoting inflammation is a" hallmark" of cancer and conventional
epidemiological studies have reported links between various inflammatory markers and …
epidemiological studies have reported links between various inflammatory markers and …
Association of glucagon-like peptide-1 receptor agonists with risk of cancers-evidence from a drug target Mendelian randomization and clinical trials
Y Sun, Y Liu, Y Dian, F Zeng, G Deng… - International Journal of …, 2024 - journals.lww.com
Background: Glucagon-like peptide-1 receptor (GLP1R) agonists have been approved by
Food and Drug Administration for management of obesity. However, the causal relationship …
Food and Drug Administration for management of obesity. However, the causal relationship …
Advance of T regulatory cells in tumor microenvironment remodeling and immunotherapy in pancreatic cancer
Z Gao, Q Zhang, X Zhang… - European Journal of …, 2022 - journals.sagepub.com
Pancreatic ductal adenocarcinoma (PDAC) is highly aggressive, deadly, and is rarely
diagnosed early. Regulatory T cells (Treg) are a multifunctional class of immunosuppressive …
diagnosed early. Regulatory T cells (Treg) are a multifunctional class of immunosuppressive …