Posttranslational modifications are covalent changes made to proteins that typically alter the
function or location of the protein. AMPylation is an emerging posttranslational modification …

During the last decade, FIC proteins have emerged as a large family comprised of a variety
of bacterial enzymes and a single member in animals. The air de famille of FIC proteins …

AMP ylation is an inactivating modification that alters the activity of the major endoplasmic
reticulum (ER) chaperone BiP to match the burden of unfolded proteins. A single ER …

We describe a method, termed cryoAPEX, which couples chemical fixation and high-
pressure freezing of cells with peroxidase tagging (APEX) to allow precise localization of …

Tenacibaculum dicentrarchi is an emerging pathogen for salmonid cultures and red conger
eel (Genypterus chilensis) in Chile, causing high economic losses not only in Chile but also …

FIC proteins regulate molecular processes from bacteria to humans by catalyzing post-
translational modifications (PTM), the most frequent being the addition of AMP or …

The intracellular bacterial pathogen Coxiella burnetii evades the host response by secreting
effector proteins that aid in establishing a replication-friendly niche. Bacterial filamentation …

Protein AMPylation refers to the covalent attachment of an AMP moiety to the amino acid
side chains of target proteins using ATP as nucleotide donor. This process is catalysed by …

The Fic (filamentation induced by cyclic AMP) domain is a widely distributed motif with a
conserved sequence of HPFx [D/E] GN [G/K] R, some of which regulate cellular activity by …

One of the major histopathological hallmarks of Parkinson's disease are Lewy bodies (LBs)–
cytoplasmic inclusions, enriched with fibrillar forms of the presynaptic protein alpha …