CD8+ T cell exhaustion and its regulatory mechanisms in the tumor microenvironment: key to the success of immunotherapy
B Zhang, J Liu, Y Mo, K Zhang, B Huang… - Frontiers in …, 2024 - frontiersin.org
A steady dysfunctional state caused by chronic antigen stimulation in the tumor
microenvironment (TME) is known as CD8+ T cell exhaustion. Exhausted-like CD8+ T cells …
microenvironment (TME) is known as CD8+ T cell exhaustion. Exhausted-like CD8+ T cells …
[HTML][HTML] Activin A induces apoptosis of human lung adenocarcinoma A549 cells through endoplasmic reticulum stress pathway
F Zhang, Y Qi, J Li, B Liu, Z Liu… - Oncology …, 2024 - spandidos-publications.com
Activin A, a member of the transforming growth factor‑β (TGF‑β) superfamily, has been
implicated in the tumorigenesis and progression of various cancers. However, it remains …
implicated in the tumorigenesis and progression of various cancers. However, it remains …
Activin A plays an essential role in migration and proliferation of hepatic stellate cells via Smad3 and calcium signaling
W Zhang, L Zhu, F Fang, F Zhang, R Wang, K Yang… - Scientific Reports, 2024 - nature.com
Activin A and hepatic stellate cells (HSCs) are involved in tissue repair and fibrosis in liver
injury. This study investigated the impact of activin A on HSC activation and migration. A …
injury. This study investigated the impact of activin A on HSC activation and migration. A …
Targeting Metastasis in Head and Neck Squamous Cell Carcinoma Using Follistatin mRNA Lipid Nanoparticles
Metastatic progression significantly reduces survival rates and complicates treatment
strategies in various cancers. Our study introduces an mRNA therapy for metastasis …
strategies in various cancers. Our study introduces an mRNA therapy for metastasis …
The role of transforming growth factor-β (TGF-β) in the formation of exhausted CD8 + T cells
R Ma, JH Sun, YY Wang - Clinical and Experimental Medicine, 2024 - Springer
CD8+ T cells exert a critical role in eliminating cancers and chronic infections, and can
provide long-term protective immunity. However, under the exposure of persistent antigen …
provide long-term protective immunity. However, under the exposure of persistent antigen …
Activin A signaling stimulates neutrophil activation and macrophage migration in pancreatitis
Acute Pancreatitis (AP) is associated with high mortality and current treatment options are
limited to supportive care. We found that blockade of activin A (activin) in mice improves …
limited to supportive care. We found that blockade of activin A (activin) in mice improves …
Activin A inhibits the migration of human lung adenocarcinoma A549 cells induced by EGF
F Zhang, X Cui, K Yang, R Guo, L Zhu, W Zhao… - International …, 2024 - Elsevier
Activin A, a member of the transforming growth factor β (TGF-β) superfamily, is involved in
tumorigenesis and tumor progression. However, it remains unclear whether activin A can …
tumorigenesis and tumor progression. However, it remains unclear whether activin A can …
[HTML][HTML] Using targeted fetal rat testis genomic and endocrine alterations to predict the effects of a phthalate mixture on the male reproductive tract
LE Gray Jr, CS Lambright, N Evans, J Ford… - Current Research in …, 2024 - Elsevier
Administration of phthalates in utero disrupts gene expression and hormone levels in the
fetal rat testis, which are key events in an Adverse Outcome Pathway (AOP) for the Phthalate …
fetal rat testis, which are key events in an Adverse Outcome Pathway (AOP) for the Phthalate …