Chronic active antibody-mediated rejection: opportunity to determine the role of interleukin-6 blockade
M Berger, M Baliker, T Van Gelder, GA Böhmig… - …, 2024 - journals.lww.com
Chronic active antibody-mediated rejection (caAMR) is arguably the most important cause of
late kidney allograft failure. However, there are no US Food and Drug Administration (FDA) …
late kidney allograft failure. However, there are no US Food and Drug Administration (FDA) …
Impact of IL-6 and IL-10 genotypes on tacrolimus dose requirements in kidney transplant recipients: Monte Carlo analysis
N Stefanović, K Danković, T Cvetković, S Vujić… - …, 2024 - Taylor & Francis
Introduction: IL-6 and IL-10 may affect the activity of cytochrome P450 (CYP) 3A enzymes
involved in tacrolimus (Tac) metabolism. Moreover, the effect of IL-6 and IL-10 on Tac …
involved in tacrolimus (Tac) metabolism. Moreover, the effect of IL-6 and IL-10 on Tac …
Carboxypeptidase B2 gene polymorphisms in the donor associate with kidney allograft loss
F Poppelaars, SK Eskandari, J Damman, A Frazer-Abel… - medRxiv, 2023 - medrxiv.org
Abstract Introduction Plasma carboxypeptidase B2 (CPB2) is an enzyme that cleaves C-
terminal amino acids from proteins, thereby regulating their activities. CPB2 has anti …
terminal amino acids from proteins, thereby regulating their activities. CPB2 has anti …
Donor genetic burden for cerebrovascular risk and kidney transplant outcome
KE Collins, E Gilbert, V Mauduit, KA Benson… - Journal of …, 2024 - Springer
Methods Using a dataset of 6666 deceased and living kidney donors from seven different
European ancestry transplant cohorts, we investigated the role of polygenic burden for …
European ancestry transplant cohorts, we investigated the role of polygenic burden for …
Synergistic impact of three complement polymorphisms in the donor, not the recipient, on long-term kidney allograft survival
F Poppelaars, M Gaya da Costa, B Faria, SK Eskandari… - medRxiv, 2023 - medrxiv.org
Background Genetic analysis in transplantation offers potential for personalized medicine.
Given the crucial role of the complement system in renal allograft injury, we investigated in …
Given the crucial role of the complement system in renal allograft injury, we investigated in …
[HTML][HTML] A non-muscle myosin heavy chain 9 genetic variant is associated with graft failure following kidney transplantation
F Poppelaars, SK Eskandari, J Damman… - Kidney Research and …, 2023 - ncbi.nlm.nih.gov
Background Despite current matching efforts to identify optimal donor-recipient pairs for
kidney transplantation, alloimmunity remains a major source of late transplant failure …
kidney transplantation, alloimmunity remains a major source of late transplant failure …
Donor genetic burden for cerebrovascular risk and kidney transplant
K Collins, E Gilbert, V Mauduit, K Benson, E Elhassan… - 2024 - repository.rcsi.com
Background and hypothesis: Kidney grafts from donors who died of stroke and related traits
have worse outcomes relative to grafts from both living donors and those who died of other …
have worse outcomes relative to grafts from both living donors and those who died of other …