Eosinophils have been shown to be potent effector cells for the killing of helminth parasites
in in vitro cultures. However, an in vivo role for eosinophils has been more difficult to …

Eosinophilia–an increase in the number of eosinophils in the blood or tissues–has
historically been recognized as a distinctive feature of helminth infections in mammals. Yet …

Abstract Type 2 cytokines (IL-4, IL-5, and IL-13) play a pivotal role in helminthic infection and
allergic disorders. CD4+ T cells which produce type 2 cytokines can be generated via IL-4 …

Exposure to infective larvae of the filarial nematode Onchocerca volvulus (Ov) either results
in patent infection (microfilaridermia) or it leads to a status called putative immunity …

To study the in vivo role of IL-4-expressing cells, we developed a strategy to tag these cells,
by generating mice in which one IL-4 allele was replaced with a cDNA encoding the human …

Onchocerciasis is a major cause of blindness. Although the World Health Organization has
been successful in reducing onchocerciasis as a public health problem in parts of West …

Helminth parasites induce strong immune responses that are initiated by cytokines, in the
first instance interleukin-4 and interleukin-13. Recent studies of knockout mice deficient in …

The conservative nature of animal evolution makes animal models the ideal tool for learning
about human biology. The Handbook of Laboratory Animal Science, Second Edition: Animal …

Onchocerca volvulus infection usually results in a predominantly immunopermissive
reaction called generalized onchocerciasis and characterized by high microfilarial burden …

The aim of this paper was to establish a suitable model for exploring the immunoregulatory
bases of the interaction of probiotics with intestinal helminth infections. The mouse …