The comprehensive anabolic effects of insulin throughout the body, in addition to the control
of glycemia, include ensuring lipid homeostasis and anti-inflammatory modulation …

Insulin-producing β cells created from human pluripotent stem cells have potential as a
therapy for insulin-dependent diabetes, but human pluripotent stem cell-derived islets (SC …

Gut stem cells are accessible by biopsy and propagate robustly in culture, offering an
invaluable resource for autologous cell therapies. Insulin-producing cells can be induced in …

A century has passed since the Nobel Prize winning discovery of insulin, which still remains
the mainstay treatment for type 1 diabetes mellitus (T1DM) to this day. True to the words of …

As a highly regenerative organ, the intestine is a promising source for cellular
reprogramming for replacing lost pancreatic β cells in diabetes. Gut enterochromaffin cells …

Immature gastrointestinal motility impedes preterm infant survival. The enteric nervous
system controls gastrointestinal motility, yet it is unknown when the human enteric nervous …

A guide from the stomach to β cells | Nature Cell Biology Skip to main content Thank you for
visiting nature.com. You are using a browser version with limited support for CSS. To obtain the …

Transplantation of stem cell-derived β-cells is a promising therapeutic advancement in the
treatment of type 1 diabetes mellitus. A current limitation of this approach is the long …

Genetic modification of non–β-cells to produce insulin is a promising therapeutic strategy for
type 1 diabetes; however, it is associated with issues, including biosafety and precise …

Objectives Insulin treatment remains the sole effective intervention for Type 1 Diabetes.
Here, we investigated the therapeutic potential of converting intestinal epithelial cells to …