UDP-glycosyltransferases in edible fungi: function, structure, and catalytic mechanism

Y Yang, Y Liang, F Cui, Y Wang, L Sun, X Zan, W Sun - Fermentation, 2023 - mdpi.com
UDP-glycosyltransferases (UGTs) are the most studied glycosyltransferases, and belong to
large GT1 family performing the key roles in antibiotic synthesis, the development of …

Fluorescent probes for bioactive detection and imaging of phase II metabolic enzymes

L Feng, J Ning, X Tian, C Wang, L Zhang, X Ma… - Coordination Chemistry …, 2019 - Elsevier
Numerous enzymes with diverse structures and functions are distributed in nature, and their
expressions and functions are easily influenced by genetic and environmental factors …

Synthesis, fungal biotransformation, and evaluation of the antimicrobial potential of chalcones with a chlorine atom

A Krawczyk-Łebek, B Żarowska, M Dymarska… - Scientific Reports, 2024 - nature.com
Chalcones are intermediate products in the biosynthesis of flavonoids, which possess a
wide range of biological properties, including antimicrobial and anticancer activities. The …

Glycosylation of quercetin by selected entomopathogenic Filamentous Fungi and prediction of its products' bioactivity

T Tronina, M Łużny, M Dymarska, M Urbaniak… - International Journal of …, 2023 - mdpi.com
Quercetin is the most abundant flavonoid in food products, including berries, apples,
cauliflower, tea, cabbage, nuts, onions, red wine and fruit juices. It exhibits various biological …

Qualitative metabolomics-based characterization of a phenolic UDP-xylosyltransferase with a broad substrate spectrum from Lentinus brumalis

E Jeong, W Kim, S Son, S Yang… - Proceedings of the …, 2023 - National Acad Sciences
Wood-decaying fungi are the major decomposers of plant litter. Heavy sequencing efforts on
genomes of wood-decaying fungi have recently been made due to the interest in their …

Combining protein and metabolic engineering to achieve green biosynthesis of 12β-O-Glc-PPD in Saccharomyces cerevisiae

C Zhou, T Chen, A Gu, Z Hu, Y Li, T Gong, J Chen… - Green …, 2023 - pubs.rsc.org
12-O-β-D-Glucopyranosyl-dammar-24-ene-3β, 12β, 20S-triol (12β-O-Glc-PPD) is a
promising candidate for the development of anti-lung cancer drugs. Currently it can only be …

Identification of novel pathways for biotransformation of tetrabromobisphenol A by Phanerochaete chrysosporium, combined with mechanism analysis at proteome …

Z Chen, H Yin, H Peng, G Lu, Z Liu, Z Dang - Science of The Total …, 2019 - Elsevier
The investigation of tetrabromobisphenol A (TBBPA) removal by Phanerochaete
chrysosporium (P. chrysosporium) was conducted. Under optimal conditions (pH 5 …

Methylglucosylation of aromatic amino and phenolic moieties of drug-like biosynthons by combinatorial biosynthesis

L Xie, L Zhang, C Wang, X Wang… - Proceedings of the …, 2018 - National Acad Sciences
Glycosylation is a prominent strategy to optimize the pharmacokinetic and
pharmacodynamic properties of drug-like small-molecule scaffolds by modulating their …

Use of a Promiscuous Glycosyltransferase from Bacillus subtilis 168 for the Enzymatic Synthesis of Novel Protopanaxatriol-Type Ginsenosides

L Dai, J Li, J Yang, Y Zhu, Y Men, Y Zeng… - Journal of agricultural …, 2018 - ACS Publications
Ginsenosides are the principal bioactive ingredients of Panax ginseng and possess diverse
notable pharmacological activities. UDP-glycosyltransferase (UGT)-mediated glycosylation …

Enzymatic glycosylation strategies in the production of bioactive compounds

A Andreu, M Ćorović, C Garcia-Sanz, AS Santos… - Catalysts, 2023 - mdpi.com
Enzymatic glycosylation is a versatile and sustainable biotechnological approach that plays
a pivotal role in the production of bioactive compounds. This process involves the enzymatic …