Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma

AJ Grossberg, LC Chu, CR Deig… - CA: a cancer journal …, 2020 - Wiley Online Library
Despite tremendous gains in the molecular understanding of exocrine pancreatic cancer,
the prognosis for this disease remains very poor, largely because of delayed disease …

Small‐molecule prodrug nanoassemblies: an emerging nanoplatform for anticancer drug delivery

G Li, B Sun, Y Li, C Luo, Z He, J Sun - Small, 2021 - Wiley Online Library
The antitumor efficiency and clinical translation of traditional nanomedicines is mainly
restricted by low drug loading, complex preparation technology, and potential toxicity …

Total neoadjuvant therapy with FOLFIRINOX in combination with losartan followed by chemoradiotherapy for locally advanced pancreatic cancer: a phase 2 clinical …

JE Murphy, JY Wo, DP Ryan, JW Clark, W Jiang… - JAMA …, 2019 - jamanetwork.com
Importance Patients with locally advanced pancreatic cancer have historically poor
outcomes. Evaluation of a total neoadjuvant approach is warranted. Objective To evaluate …

[HTML][HTML] The current treatment paradigm for pancreatic ductal adenocarcinoma and barriers to therapeutic efficacy

DR Principe, PW Underwood, M Korc… - Frontiers in …, 2021 - frontiersin.org
Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis, with a median survival
time of 10-12 months. Clinically, these poor outcomes are attributed to several factors …

An update on treatment options for pancreatic adenocarcinoma

A Lambert, L Schwarz, I Borbath… - … in medical oncology, 2019 - journals.sagepub.com
Pancreatic cancer is one of the most lethal solid organ tumors. Due to the rising incidence,
late diagnosis, and limited treatment options, it is expected to be the second leading cause …

Chemotherapy for pancreatic cancer

C Springfeld, D Jäger, MW Büchler, O Strobel… - La Presse Medicale, 2019 - Elsevier
Chemotherapy is an important part of multimodality pancreatic cancer treatment. After
curative resection, adjuvant chemotherapy can significantly improve disease free survival …

Emerging nanotherapeutics for facilitating photodynamic therapy

S Li, F Yang, Y Wang, T Du, X Hou - Chemical Engineering Journal, 2023 - Elsevier
Photodynamic therapy (PDT) with selectivity and security has been widely acknowledged as
a promising therapeutic option for cancer treatment. With the swift blossom of phototherapy …

Meta-analysis of recurrence pattern after resection for pancreatic cancer

M Tanaka, AL Mihaljevic, P Probst… - Journal of British …, 2019 - academic.oup.com
Background Initial recurrence mapping of resected pancreatic ductal adenocarcinoma
(PDAC) could help in stratifying patient subpopulations for optimal postoperative follow-up …

Neoadjuvant chemotherapy in pancreatic cancer: an appraisal of the current high-level evidence

PC Müller, MC Frey, CM Ruzza, F Nickel, C Jost… - Pharmacology, 2021 - karger.com
At the time of diagnosis, only about 20% of patients with pancreatic ductal adenocarcinoma
(PDAC) have resectable disease. PDAC treatment necessitates a multidisciplinary …

Barriers and opportunities for gemcitabine in pancreatic cancer therapy

AK Beutel, CJ Halbrook - American Journal of Physiology …, 2023 - journals.physiology.org
Pancreatic ductal adenocarcinoma (PDA) has become one of the leading causes of cancer-
related deaths across the world. A lack of durable responses to standard-of-care …