Macrophages: the good, the bad, and the gluttony
Macrophages are dynamic cells that play critical roles in the induction and resolution of
sterile inflammation. In this review, we will compile and interpret recent findings on the …
sterile inflammation. In this review, we will compile and interpret recent findings on the …
Fibroblasts as immune regulators in infection, inflammation and cancer
In chronic infection, inflammation and cancer, the tissue microenvironment controls how
local immune cells behave, with tissue-resident fibroblasts emerging as a key cell type in …
local immune cells behave, with tissue-resident fibroblasts emerging as a key cell type in …
Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial
Patients with rheumatoid arthritis (RA) receive highly targeted biologic therapies without
previous knowledge of target expression levels in the diseased tissue. Approximately 40 …
previous knowledge of target expression levels in the diseased tissue. Approximately 40 …
Synovial tissue macrophages in joint homeostasis, rheumatoid arthritis and disease remission
M Kurowska-Stolarska, S Alivernini - Nature Reviews Rheumatology, 2022 - nature.com
Synovial tissue macrophages (STMs) were principally recognized as having a pro-
inflammatory role in rheumatoid arthritis (RA), serving as the main producers of pathogenic …
inflammatory role in rheumatoid arthritis (RA), serving as the main producers of pathogenic …
[HTML][HTML] Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis (R4RA): 16-week outcomes of a stratified, biopsy-driven …
Background Although targeted biological treatments have transformed the outlook for
patients with rheumatoid arthritis, 40% of patients show poor clinical response, which is …
patients with rheumatoid arthritis, 40% of patients show poor clinical response, which is …
Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry
To define the cell populations that drive joint inflammation in rheumatoid arthritis (RA), we
applied single-cell RNA sequencing (scRNA-seq), mass cytometry, bulk RNA sequencing …
applied single-cell RNA sequencing (scRNA-seq), mass cytometry, bulk RNA sequencing …
Age and age-related diseases: role of inflammation triggers and cytokines
IM Rea, DS Gibson, V McGilligan… - Frontiers in …, 2018 - frontiersin.org
Cytokine dysregulation is believed to play a key role in the remodeling of the immune
system at older age, with evidence pointing to an inability to fine-control systemic …
system at older age, with evidence pointing to an inability to fine-control systemic …
Stem cell-derived exosomes as nanotherapeutics for autoimmune and neurodegenerative disorders
To dissect therapeutic mechanisms of transplanted stem cells and develop exosome-based
nanotherapeutics in treating autoimmune and neurodegenerative diseases, we assessed …
nanotherapeutics in treating autoimmune and neurodegenerative diseases, we assessed …
Immunopathogenesis of rheumatoid arthritis
GS Firestein, IB McInnes - Immunity, 2017 - cell.com
Rheumatoid arthritis (RA) is the most common inflammatory arthropathy. The majority of
evidence, derived from genetics, tissue analyses, models, and clinical studies, points to an …
evidence, derived from genetics, tissue analyses, models, and clinical studies, points to an …
Molecular portraits of early rheumatoid arthritis identify clinical and treatment response phenotypes
There is a current imperative to unravel the hierarchy of molecular pathways that drive the
transition of early to established disease in rheumatoid arthritis (RA). Herein, we report a …
transition of early to established disease in rheumatoid arthritis (RA). Herein, we report a …