Optimal cardiac function depends on proper timing of excitation and contraction in various
regions of the heart, as well as on appropriate heart rate. This is accomplished via …

Alternative splicing (AS) of protein-coding messenger RNAs is an essential regulatory
mechanism in eukaryotic gene expression that controls the proper function of proteins. It is …

RNA binding proteins (RBPs) orchestrate the production, processing, and function of
mRNAs. Here, we present the affinity landscapes of 78 human RBPs using an unbiased …

Oxidative phosphorylation (OXPHOS) and glycolysis are the two major pathways for ATP
production. The reliance on each varies across tissues and cell states, and can influence …

Human pluripotent stem cell (hPSC) technology has offered nearly infinite opportunities to
model all kinds of human diseases in vitro. Cardiomyocytes derived from hPSCs have …

Current therapies for arrhythmia using ion channel blockade, catheter ablation, or an
implantable cardioverter defibrillator have limitations, and it is important to search for new …

RNA splicing represents a post-transcriptional mechanism to generate multiple functional
RNAs or proteins from a single transcript. The evolution of RNA splicing is a prime example …

Background Resveratrol has shown benefits in reducing ventricular remodeling and
arrhythmias. Objective This study aimed to assess the therapeutic efficacy of resveratrol in …

The voltage-gated cardiac Na+ channel (Nav1. 5), encoded by the SCN5A gene, conducts
the inward depolarizing cardiac Na+ current (I Na) and is vital for normal cardiac electrical …

Cancer sequencing studies have implicated regulators of pre-mRNA splicing as important
disease determinants in acute myeloid leukemia (AML), but the underlying mechanisms …