[HTML][HTML] Biomolecular condensates at sites of DNA damage: more than just a phase
V Spegg, M Altmeyer - DNA repair, 2021 - Elsevier
Protein recruitment to DNA break sites is an integral part of the DNA damage response
(DDR). Elucidation of the hierarchy and temporal order with which DNA damage sensors as …
(DDR). Elucidation of the hierarchy and temporal order with which DNA damage sensors as …
[HTML][HTML] On the potential of machine learning to examine the relationship between sequence, structure, dynamics and function of intrinsically disordered proteins
K Lindorff-Larsen, BB Kragelund - Journal of Molecular Biology, 2021 - Elsevier
Intrinsically disordered proteins (IDPs) constitute a broad set of proteins with few uniting and
many diverging properties. IDPs—and intrinsically disordered regions (IDRs) interspersed …
many diverging properties. IDPs—and intrinsically disordered regions (IDRs) interspersed …
Physics-driven coarse-grained model for biomolecular phase separation with near-quantitative accuracy
Various physics-and data-driven sequence-dependent protein coarse-grained models have
been developed to study biomolecular phase separation and elucidate the dominant …
been developed to study biomolecular phase separation and elucidate the dominant …
Deciphering how naturally occurring sequence features impact the phase behaviours of disordered prion-like domains
Prion-like low-complexity domains (PLCDs) have distinctive sequence grammars that
determine their driving forces for phase separation. Here we uncover the physicochemical …
determine their driving forces for phase separation. Here we uncover the physicochemical …
Accurate model of liquid–liquid phase behavior of intrinsically disordered proteins from optimization of single-chain properties
Many intrinsically disordered proteins (IDPs) may undergo liquid–liquid phase separation
(LLPS) and participate in the formation of membraneless organelles in the cell, thereby …
(LLPS) and participate in the formation of membraneless organelles in the cell, thereby …
Defining the condensate landscape of fusion oncoproteins
Fusion oncoproteins (FOs) arise from chromosomal translocations in~ 17% of cancers and
are often oncogenic drivers. Although some FOs can promote oncogenesis by undergoing …
are often oncogenic drivers. Although some FOs can promote oncogenesis by undergoing …
[HTML][HTML] Improved predictions of phase behaviour of intrinsically disordered proteins by tuning the interaction range
G Tesei, K Lindorff-Larsen - Open Research Europe, 2023 - pmc.ncbi.nlm.nih.gov
The formation and viscoelastic properties of condensates of intrinsically disordered proteins
(IDPs) is dictated by amino acid sequence and solution conditions. Because of the …
(IDPs) is dictated by amino acid sequence and solution conditions. Because of the …
Implementation of residue-level coarse-grained models in GENESIS for large-scale molecular dynamics simulations
Residue-level coarse-grained (CG) models have become one of the most popular tools in
biomolecular simulations in the trade-off between modeling accuracy and computational …
biomolecular simulations in the trade-off between modeling accuracy and computational …
Design of intrinsically disordered protein variants with diverse structural properties
Intrinsically disordered proteins (IDPs) perform a broad range of functions in biology,
suggesting that the ability to design IDPs could help expand the repertoire of proteins with …
suggesting that the ability to design IDPs could help expand the repertoire of proteins with …
Thermodynamic origins of two-component multiphase condensates of proteins
Intracellular condensates are highly multi-component systems in which complex phase
behaviour can ensue, including the formation of architectures comprising multiple …
behaviour can ensue, including the formation of architectures comprising multiple …