Neurodegenerative diseases (NDDs) are predicted to be the biggest health concern in this
century and the second leading cause of death by 2050. The main risk factor of these …

Basic experimental stem cell research has opened up the possibility of many diverse clinical
applications; however, translation to clinical trials has been restricted to only a few diseases …

Neurodegenerative diseases are characterized by a progressive loss of neurons in the brain
or spinal cord that leads to a loss of function of the affected areas. The lack of effective …

Nrf2 (nuclear erythroid 2‐related factor 2) is a basic region leucine‐zipper transcription
factor which binds to the antioxidant response element (ARE) and thereby regulates the …

Objectives Sarcopenia, age-related muscle wasting, is associated with increased morbidity
and mortality in the affected individuals. The pathogenesis of sarcopenia is not yet fully …

Introduction: The importance of microglia in most neurodegenerative pathologies, from
Parkinson's disease to amyotrophic lateral sclerosis and Alzheimer's disease, is increasingly …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease associated with
motor neuron degeneration, muscle weakness, paralysis and finally death. The proposed …

Amyotrophic lateral sclerosis (ALS), commonly termed as motor neuron disease (MND) in
UK, is a chronically lethal disorder among the neurodegenerative diseases, meanwhile. ALS …

Background Amyotrophic lateral sclerosis (ALS) is a motor neuron disease (MND) that
typically causes death within 3-5 years after diagnosis. Regardless of the substantial …

Significance: Half a century of research provided unambiguous proof that superoxide and
species derived from it—reactive oxygen species (ROS)—play a central role in many …