[HTML][HTML] Red blood cell storage lesion: causes and potential clinical consequences
T Yoshida, M Prudent, A D'Alessandro - Blood Transfusion, 2019 - ncbi.nlm.nih.gov
Red blood cells (RBCs) are a specialised organ that enabled the evolution of multicellular
organisms by supplying a sufficient quantity of oxygen to cells that cannot obtain oxygen …
organisms by supplying a sufficient quantity of oxygen to cells that cannot obtain oxygen …
[HTML][HTML] Red blood cell metabolism in vivo and in vitro
Red blood cells (RBC) are the most abundant cell in the human body, with a central role in
oxygen transport and its delivery to tissues. However, omics technologies recently revealed …
oxygen transport and its delivery to tissues. However, omics technologies recently revealed …
[HTML][HTML] Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance
EL Giddings, DP Champagne, MH Wu, JM Laffin… - Nature …, 2021 - nature.com
Chemotherapy remains the standard of care for most cancers worldwide, however
development of chemoresistance due to the presence of the drug-effluxing ATP binding …
development of chemoresistance due to the presence of the drug-effluxing ATP binding …
Mechanisms of red blood cell transfusion‐related immunomodulation
Red blood cell (RBC) transfusion is common in critically ill, postsurgical, and posttrauma
patients in whom both systemic inflammation and immune suppression are associated with …
patients in whom both systemic inflammation and immune suppression are associated with …
A three‐minute method for high‐throughput quantitative metabolomics and quantitative tracing experiments of central carbon and nitrogen pathways
Rationale The implementation of mass spectrometry (MS)‐based metabolomics is
advancing many areas of biomedical research. The time associated with traditional …
advancing many areas of biomedical research. The time associated with traditional …
[HTML][HTML] Donor sex, age and ethnicity impact stored red blood cell antioxidant metabolism through mechanisms in part explained by glucose 6-phosphate …
Red blood cell (RBC) storage in the blood bank promotes the progressive accumulation of
metabolic alterations that may ultimately impact the erythrocyte capacity to cope with oxidant …
metabolic alterations that may ultimately impact the erythrocyte capacity to cope with oxidant …
Oxidative modifications of glyceraldehyde 3-phosphate dehydrogenase regulate metabolic reprogramming of stored red blood cells
JA Reisz, MJ Wither, M Dzieciatkowska… - Blood, The Journal …, 2016 - ashpublications.org
Abstract Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) plays a key regulatory
function in glucose oxidation by mediating fluxes through glycolysis or the pentose …
function in glucose oxidation by mediating fluxes through glycolysis or the pentose …
[HTML][HTML] Hypoxia modulates the purine salvage pathway and decreases red blood cell and supernatant levels of hypoxanthine during refrigerated storage
Hypoxanthine catabolism in vivo is potentially dangerous as it fuels production of urate and,
most importantly, hydrogen peroxide. However, it is unclear whether accumulation of …
most importantly, hydrogen peroxide. However, it is unclear whether accumulation of …
Three-minute method for amino acid analysis by UHPLC and high-resolution quadrupole orbitrap mass spectrometry
Amino acid analysis is a powerful bioanalytical technique for many biomedical research
endeavors, including cancer, emergency medicine, nutrition and neuroscience research. In …
endeavors, including cancer, emergency medicine, nutrition and neuroscience research. In …
Transfusion-related acute lung injury (TRALI): potential pathways of development, strategies for prevention and treatment, and future research directions
Transfusion-related acute lung injury (TRALI) can occur during or after a transfusion, and
remains a leading cause of transfusion-associated morbidity and mortality. TRALI is caused …
remains a leading cause of transfusion-associated morbidity and mortality. TRALI is caused …