Skeletal disorders are among the leading debilitating factors affecting millions of people
worldwide. The use of stem cells for tissue repair has raised many promises in various …

Intervertebral disc degeneration (IVDD) occurs as a result of an imbalance of the anabolic
and catabolic processes in the intervertebral disc, leading to an alteration in the composition …

Background: Opioid use, abuse, and adverse consequences, including death, have
escalated at an alarming rate since the 1990s. In an attempt to control opioid abuse …

Intervertebral disc degeneration (IVDD) is a multi-factorial process characterized by
phenotypic and genotypic changes, which leads to low back pain and disability. Prolonged …

BACKGROUND: Regenerative medicine is a medical subspecialty that seeks to recruit and
enhance the body's own inherent healing armamentarium in the treatment of patient …

Background: Several cell-based therapies have been proposed in recent years the
management of low back pain, including the injection of medicinal signaling cells or …

Low back pain (LBP) in one of the most disabling symptoms affecting nearly 80% of the
population worldwide. Its primary cause seems to be intervertebral disc degeneration (IDD) …

Intervertebral disc (IVD) degeneration (IDD) is one of the major causes of back pain, a
condition that represents a serious socio-economic burden. Deeper knowledge of the …

Today, the application of mesenchymal stromal/stem cells (MSCs) and their exosomes to
treat degenerative diseases has received attention. Due to the characteristics of these cells …

Lower back pain (LBP) occurs in 80% of adults in their lifetime; resulting in LBP being one of
the biggest causes of disability worldwide. Chronic LBP has been linked to the degeneration …