Peroxynitrite is a short-lived and reactive biological oxidant formed from the diffusion-
controlled reaction of the free radicals superoxide (O2•–) and nitric oxide (• NO). In this …

The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

We summarize here results of studies designed to elucidate basic mechanisms of reactive
oxygen (ROS)-mediated oxidation of proteins and free amino acids. These studies have …

Superoxide (O2-.), nitric oxide (. NO), and their reaction product peroxynitrite (ONOO-) have
all been shown to independently exert toxic target molecule reactions. Because these …

Mitochondria constitute a primary locus for the intracellular formation and reactions of
peroxynitrite, and these interactions are recognized to contribute to the biological and …

Although different theories have been proposed to explain the aging process, it is generally
agreed that there is a correlation between aging and the accumulation of oxidatively …

Nitric oxide (NO) and its derivative peroxynitrite (ONOO−) inhibit mitochondrial respiration by
distinct mechanisms. Low (nanomolar) concentrations of NO specifically inhibit cytochrome …

Peroxynitrite, the product of the fast reaction between nitric oxide (• NO) and superoxide O
2•− radicals, is an oxidizing and nitrating agent which is able to traverse biological …

Inflammatory processes in chronic rejection remain a serious clinical problem in organ
transplantation. Activated cellular infiltrate produces high levels of both superoxide and nitric …

Nitric oxide (NO) has several essential roles in mammals, but unregulated NO production
can cause cell death through oxidative stress, disrupted energy metabolism, DNA damage …