UBR5 is a nuclear E3 ligase that ubiquitinates a vast range of substrates for proteasomal
degradation. This HECT domain‐containing ubiquitin ligase has recently been identified as …

Cytoplasmic mislocalization of the TAR-DNA binding protein of 43 kDa (TDP-43) leads to
large, insoluble aggregates that are a hallmark of amyotrophic lateral sclerosis and …

Macromolecular complexes of proteins and RNAs are essential building blocks of cells.
These stable supramolecular particles can be viewed as minimal biochemical units whose …

The human UBR5 is a single polypeptide chain homology to E6AP C terminus (HECT)-type
E3 ubiquitin ligase essential for embryonic development in mammals. Dysregulated UBR5 …

Highlights•Most OMBBs evolved from an ancestral β-hairpin structure through a distinct
divergent evolutionary pathway.•Eukaryotic OMBBs evolved from that same l β-hairpin, but …

Mechanisms of emergence and divergence of protein folds pose central questions in
biological sciences. Incremental mutation and stepwise adaptation explain relationships …

Bacteria are under constant assault by bacteriophages and other mobile genetic elements.
As a result, bacteria have evolved a multitude of systems that protect from attack. Genes …

Rossmann folds are ancient, frequently diverged domains found in many biological reaction
pathways where they have adapted for different functions. Consequently, discernment and …

SH3 and OB are the simplest, oldest, and most common protein domains within the
translation system. SH3 and OB domains are β-barrels that are structurally similar but are …

Bulky cargos like procollagens, apolipoproteins, and mucins exceed the size of conventional
COPII vesicles. During evolution a process emerged in metazoans, predominantly governed …