Entry into mitosis is triggered by the activation of cyclin‐dependent kinase 1 (Cdk1). This
simple reaction rapidly and irreversibly sets the cell up for division. Even though the core …

In the decade since their discovery, the PH domain leucine-rich repeat protein
phosphatases (PHLPP) have emerged as critical regulators of cellular homeostasis, and …

PP2A is a major tumor suppressor whose inactivation is frequently found in a wide spectrum
of human tumors. In particular, deletion or epigenetic silencing of genes encoding the B55 …

PP2A is a highly conserved eukaryotic serine/threonine protein phosphatase of the PPP
family of phosphatases with fundamental cellular functions. In cells, PP2A targets specific …

The AKT‐mTOR pathway is a central regulator of cell growth and metabolism. Upon
sustained mTOR activity, AKT activity is attenuated by a feedback loop that restrains …

MASTL kinase is essential for correct progression through mitosis, with loss of MASTL
causing chromosome segregation errors, mitotic collapse and failure of cytokinesis …

Mitosis is controlled by a subtle balance between kinase and phosphatase activities that
involve the master mitotic kinase cyclin-B–Cdk1 and its antagonizing protein phosphatase …

Abstract The Greatwall/Ensa/PP2A-B55 pathway is essential for controlling mitotic substrate
phosphorylation and mitotic entry. Here, we investigate the effect of the knockdown of the …

Protein phosphorylation is a reversible post-translation modification essential in cell
signaling. This study addresses a long-standing question as to how the most abundant …

Pancreatic cancer (PC) remains a major cause of cancer-related deaths primarily due to its
inherent potential of therapy resistance. Checkpoint inhibitors have emerged as promising …