Abstract Three-dimensional (3D) cell culture has tremendous advantages to closely mimic
the in vivo architecture and microenvironment of healthy tissue and organs, as well as of …

The complexity of cancer biology and its clinical manifestation are driven by genetic,
epigenetic, transcriptomic, proteomic and metabolomic alterations, supported by genomic …

Background and objective Predicting response to therapy for each patient's tumor is critical
to improving long-term outcomes for muscle-invasive bladder cancer. This study aims to …

Identifying drug-resistant cancer cells is of fundamental importance to afford disease and
find the most effective therapies for the patients. Recently, label-free imaging flow cytometry …

Simple Summary Primary culture of cancer cells from patient tumors in a physiologically
relevant system can provide information about tumor biology, disentangle the role of …

About 75% of epithelial ovarian cancer (EOC) patients suffer from relapsing and develop
drug resistance after primary chemotherapy. The commonly used clinical examinations and …

Preclinical knowledge of dysregulated pathways and potential biomarkers for urological
cancers has undergone limited translation into the clinic. Moreover, the low approval rate of …

The acquired drug chemoresistance represents the main challenge of the ovarian cancer
treatment. In addition, the absence of an adequate in vitro model able to reproduce the …

Inter-patient and intra-tumour heterogeneity (ITH) have prompted the need for a more
personalised approach to cancer therapy. Although patient-derived xenograft (PDX) models …

Glioblastoma (GBM) is one of the most malignant primary brain tumors. This neoplasm is the
hardest to treat and has a bad prognosis. Because of the characteristics of genetic …