Heat shock proteins (HSPs) constitute a large family of proteins involved in protein folding
and maturation whose expression is induced by heat shock or other stressors. The major …

Heat shock proteins (HSPs) are a large family of chaperones that are involved in protein
folding and maturation of a variety of “client” proteins protecting them from degradation …

Lung cancer is the leading cause of cancer-related deaths worldwide, with non-small cell
lung cancer (NSCLC) being the predominant histological subtype. Despite the emergence of …

In the past few decades, the development of heat shock protein 90 (Hsp90) inhibitors for
cancer treatment has not stopped. About twenty compounds have been evaluated in the …

Despite significant advances in cancer diagnostics and therapeutics the majority of cancer
unfortunately remains incurable, which has led to continued research to better understand …

Multiple myeloma (MM) is a plasma-cell malignancy which remains incurable despite the
recent emergence of multiple novel agents. Importantly, recent genetic and molecular …

The molecular chaperone HSP90 plays a crucial role in cancer cell growth and survival by
stabilizing cancer-related proteins. A number of HSP90 inhibitors have been developed …

Hallmarks of cancer, including rapid growth and aneuploidy, can result in non-oncogene
addiction to the proteostasis network that can be exploited clinically. The defining example is …

The molecular chaperone heat shock protein 90 (HSP90) is a promising target for cancer
therapy, as it assists in the stabilization of cancer-related proteins, promoting cancer cell …

An acid-labile dextran–bortezomib conjugate (Dex–BTZ), ie, a macromolecularized
proteasome inhibitor, is synthesized by a boron esterification reaction. The prodrug exhibits …