Traumatic brain injury: mechanisms of glial response
Traumatic brain injury (TBI) is a heterogeneous disorder that involves brain damage due to
external forces. TBI is the main factor of death and morbidity in young males with a high …
external forces. TBI is the main factor of death and morbidity in young males with a high …
Inflammation: the link between comorbidities, genetics, and Alzheimer's disease
EA Newcombe, J Camats-Perna, ML Silva… - Journal of …, 2018 - Springer
Alzheimer's disease (AD) is a neurodegenerative disorder, most cases of which lack a clear
causative event. This has made the disease difficult to characterize and, thus, diagnose …
causative event. This has made the disease difficult to characterize and, thus, diagnose …
Astrocyte roles in traumatic brain injury
JE Burda, AM Bernstein, MV Sofroniew - Experimental neurology, 2016 - Elsevier
Astrocytes sense changes in neural activity and extracellular space composition. In
response, they exert homeostatic mechanisms critical for maintaining neural circuit function …
response, they exert homeostatic mechanisms critical for maintaining neural circuit function …
The NLRP3 inflammasome in traumatic brain injury: potential as a biomarker and therapeutic target
There is a great clinical need to identify the underlying mechanisms, as well as related
biomarkers, and treatment targets, for traumatic brain injury (TBI). Neuroinflammation is a …
biomarkers, and treatment targets, for traumatic brain injury (TBI). Neuroinflammation is a …
Role of nuclear factor kappa B (NF-κB) signalling in neurodegenerative diseases: an mechanistic approach
S Singh, TG Singh - Current Neuropharmacology, 2020 - ingentaconnect.com
A transcriptional regulatory nuclear factor kappa B (NF-ΚB) protein is a modulator of cellular
biological activity via binding to a promoter region in the nucleus and transcribing various …
biological activity via binding to a promoter region in the nucleus and transcribing various …
Pathophysiological responses and roles of astrocytes in traumatic brain injury
S Michinaga, Y Koyama - International journal of molecular sciences, 2021 - mdpi.com
Traumatic brain injury (TBI) is immediate damage caused by a blow to the head resulting
from traffic accidents, falls, and sporting activity, which causes death or serious disabilities in …
from traffic accidents, falls, and sporting activity, which causes death or serious disabilities in …
The complexity of neuroinflammation consequent to traumatic brain injury: from research evidence to potential treatments
MC Morganti-Kossmann, BD Semple, SC Hellewell… - Acta …, 2019 - Springer
This review recounts the definitions and research evidence supporting the multifaceted roles
of neuroinflammation in the injured brain following trauma. We summarise the literature …
of neuroinflammation in the injured brain following trauma. We summarise the literature …
Nuclear factor‐kappa β as a therapeutic target for Alzheimer's disease
Alzheimer's disease (AD) is a typical progressive, chronic neurodegenerative disorder with
worldwide prevalence. Its clinical manifestation involves the presence of extracellular …
worldwide prevalence. Its clinical manifestation involves the presence of extracellular …
The role of NLRP3 inflammasome in the pathogenesis of traumatic brain injury
Traumatic brain injury (TBI) represents an important problem of global health. The damage
related to TBI is first due to the direct injury and then to a secondary phase in which …
related to TBI is first due to the direct injury and then to a secondary phase in which …
Nuclear factor-kappa B and Alzheimer disease, unifying genetic and environmental risk factors from cell to humans
SV Jones, I Kounatidis - Frontiers in immunology, 2017 - frontiersin.org
Alzheimer's disease (AD) is the most common form of dementia, an eversible, progressive
disease that causes problems with memory, thinking, language, planning, and behavior …
disease that causes problems with memory, thinking, language, planning, and behavior …