Traumatic brain injury: mechanisms of glial response

RG Mira, M Lira, W Cerpa - Frontiers in physiology, 2021 - frontiersin.org
Traumatic brain injury (TBI) is a heterogeneous disorder that involves brain damage due to
external forces. TBI is the main factor of death and morbidity in young males with a high …

Inflammation: the link between comorbidities, genetics, and Alzheimer's disease

EA Newcombe, J Camats-Perna, ML Silva… - Journal of …, 2018 - Springer
Alzheimer's disease (AD) is a neurodegenerative disorder, most cases of which lack a clear
causative event. This has made the disease difficult to characterize and, thus, diagnose …

Astrocyte roles in traumatic brain injury

JE Burda, AM Bernstein, MV Sofroniew - Experimental neurology, 2016 - Elsevier
Astrocytes sense changes in neural activity and extracellular space composition. In
response, they exert homeostatic mechanisms critical for maintaining neural circuit function …

The NLRP3 inflammasome in traumatic brain injury: potential as a biomarker and therapeutic target

WT O'Brien, L Pham, GF Symons, M Monif… - Journal of …, 2020 - Springer
There is a great clinical need to identify the underlying mechanisms, as well as related
biomarkers, and treatment targets, for traumatic brain injury (TBI). Neuroinflammation is a …

Role of nuclear factor kappa B (NF-κB) signalling in neurodegenerative diseases: an mechanistic approach

S Singh, TG Singh - Current Neuropharmacology, 2020 - ingentaconnect.com
A transcriptional regulatory nuclear factor kappa B (NF-ΚB) protein is a modulator of cellular
biological activity via binding to a promoter region in the nucleus and transcribing various …

Pathophysiological responses and roles of astrocytes in traumatic brain injury

S Michinaga, Y Koyama - International journal of molecular sciences, 2021 - mdpi.com
Traumatic brain injury (TBI) is immediate damage caused by a blow to the head resulting
from traffic accidents, falls, and sporting activity, which causes death or serious disabilities in …

The complexity of neuroinflammation consequent to traumatic brain injury: from research evidence to potential treatments

MC Morganti-Kossmann, BD Semple, SC Hellewell… - Acta …, 2019 - Springer
This review recounts the definitions and research evidence supporting the multifaceted roles
of neuroinflammation in the injured brain following trauma. We summarise the literature …

Nuclear factor‐kappa β as a therapeutic target for Alzheimer's disease

NK Jha, SK Jha, R Kar, P Nand, K Swati… - Journal of …, 2019 - Wiley Online Library
Alzheimer's disease (AD) is a typical progressive, chronic neurodegenerative disorder with
worldwide prevalence. Its clinical manifestation involves the presence of extracellular …

The role of NLRP3 inflammasome in the pathogenesis of traumatic brain injury

N Irrera, M Russo, G Pallio, A Bitto, F Mannino… - International journal of …, 2020 - mdpi.com
Traumatic brain injury (TBI) represents an important problem of global health. The damage
related to TBI is first due to the direct injury and then to a secondary phase in which …

Nuclear factor-kappa B and Alzheimer disease, unifying genetic and environmental risk factors from cell to humans

SV Jones, I Kounatidis - Frontiers in immunology, 2017 - frontiersin.org
Alzheimer's disease (AD) is the most common form of dementia, an eversible, progressive
disease that causes problems with memory, thinking, language, planning, and behavior …