Impaired neurodevelopmental pathways in autism spectrum disorder: a review of signaling mechanisms and crosstalk

S Kumar, K Reynolds, Y Ji, R Gu, S Rai… - Journal of …, 2019 - Springer
Background The development of an autistic brain is a highly complex process as evident
from the involvement of various genetic and non-genetic factors in the etiology of the autism …

[HTML][HTML] Repetitive restricted behaviors in autism spectrum disorder: from mechanism to development of therapeutics

J Tian, X Gao, L Yang - Frontiers in neuroscience, 2022 - frontiersin.org
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized
by deficits in social communication, social interaction, and repetitive restricted behaviors …

Cathepsin B inhibitor alleviates Th1, Th17, and Th22 transcription factor signaling dysregulation in experimental autoimmune encephalomyelitis

MA Ansari, A Nadeem, MA Alshammari, SM Attia… - Experimental …, 2022 - Elsevier
Multiple sclerosis (MS) is an autoimmune disease characterized by inflammatory infiltration
in association with demyelination in the central nervous system. Among the factors involved …

Adenosine receptors in neuropsychiatric disorders: fine regulators of neurotransmission and potential therapeutic targets

S Pasquini, C Contri, S Merighi, S Gessi… - International Journal of …, 2022 - mdpi.com
Adenosine exerts an important role in the modulation of central nervous system (CNS)
activity. Through the interaction with four G-protein coupled receptor (GPCR) subtypes …

Systemic maternal inflammation promotes ASD via IL-6 and IFN-γ

D Majerczyk, EG Ayad, KL Brewton, P Saing… - Bioscience …, 2022 - portlandpress.com
Autism spectrum disorder (ASD) is a neurological disorder that manifests during early
development, impacting individuals through their ways of communicating, social behaviors …

[HTML][HTML] Inflammation and myeloid cells in cancer progression and metastasis

J Deng, JB Fleming - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
To date, the most immunotherapy drugs act upon T cell surface proteins to promote
tumoricidal T cell activity. However, this approach has to date been unsuccessful in certain …

Icariin alleviates autistic-like behavior, hippocampal inflammation and vGlut1 expression in adult BTBR mice

P Jiang, L Zhou, Z Du, L Zhao, Y Tang, X Fei… - Behavioural Brain …, 2023 - Elsevier
Autism spectrum disorder (ASD) is a complicated, heterogeneous disorder characterized by
social interaction deficits and repetitive stereotypical behaviors. Neuroinflammation and …

Zika virus as a possible risk factor for autism spectrum disorder: neuroimmunological aspects

P Vianna, JA Gomes, JA Boquett, LR Fraga… - …, 2019 - karger.com
The recent outbreak of the Zika virus (ZIKV) and the discovery that perinatal Zika exposure
can lead to the Congenital Zika Syndrome has promoted a call for prevention measures …

Resveratrol inhibits AhR/Notch axis and reverses Th17/Treg imbalance in purpura by activating Foxp3

J Cheng, S Wang, SQ Lv, Y Song… - Toxicology Research, 2023 - academic.oup.com
Background Resveratrol has been reported to reverse the imbalance of T helper
17/regulatory T (Th17/Treg) by inhibiting the aryl hydrocarbon receptor pathway to treat …

Resveratrol Improves Neuroimmune Dysregulation Through the Inhibition of Neuronal Toll-Like Receptors and COX-2 Signaling in BTBR T+ Itpr3tf/J Mice

SF Ahmad, MA Ansari, A Nadeem, MZ Alzahrani… - Neuromolecular …, 2018 - Springer
Autism is a neurodevelopmental disorder characterized by deficits in qualitative impairments
in communication, repetitive and social interaction, restricted, and stereotyped patterns of …