In the field of hereditary spastic paraplegia (HSP), progress in molecular diagnostics needs
to be translated into robust phenotyping studies to understand genetic and phenotypic …

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Background/purpose Hereditary spastic paraplegia (HSP) is a heterogeneous group of
inherited neurodegenerative disorders characterized by slowly progressive lower limbs …

Hereditary spastic paraplegia (HSP) is a group of neurodegenerative diseases with genetic
and clinical heterogeneity characterized by spasticity and weakness of the lower limbs. It …

Objective: The aim of this study was to confirm the disease causing of a family with
hereditary spastic paraplegia. Methods: Detailed clinical characterization analysis was …

Spastic paraplegia 15 (SPG15), typically an early-onset complex hereditary spastic
paraplegia, is characterized by progressive spasticity that begins in the lower extremities …

Background: Emerging studies have shown that a variety of gene mutations occur in
development and progression of cancer and highly mutation genes could play oncogenic or …