Novel targets, treatments, and advanced models for intracerebral haemorrhage

M Zille, TD Farr, RF Keep, C Römer, G Xi, J Boltze - EBioMedicine, 2022 - thelancet.com
Intracerebral haemorrhage (ICH) is the second most common type of stroke and a major
cause of mortality and disability worldwide. Despite advances in surgical interventions and …

Progress in translational research on intracerebral hemorrhage: is there an end in sight?

G Xi, J Strahle, Y Hua, RF Keep - Progress in neurobiology, 2014 - Elsevier
Intracerebral hemorrhage (ICH) is a common and often fatal stroke subtype for which
specific therapies and treatments remain elusive. To address this, many recent experimental …

Comparisons between Garcia, Modo, and Longa rodent stroke scales: Optimizing resource allocation in rat models of focal middle cerebral artery occlusion

SP Bachour, M Hevesi, O Bachour, BM Sweis… - Journal of the …, 2016 - Elsevier
The use of rodent stroke models allow for the understanding of stroke pathophysiology.
There is currently no gold standard neurological assessment to measure deficits and …

Targeting secondary hematoma expansion in spontaneous intracerebral hemorrhage–state of the art

J Guan, GWJ Hawryluk - Frontiers in neurology, 2016 - frontiersin.org
Spontaneous intracerebral hemorrhage (SICH), defined broadly as intracerebral
hemorrhage not related to trauma, results in long-term disability or death in a large …

Non-invasive Vagus nerve stimulation improves brain lesion volume and neurobehavioral outcomes in a rat model of traumatic brain injury

AA Divani, P Salazar, HA Ikram, E Taylor… - Journal of …, 2023 - liebertpub.com
Traumatic brain injury (TBI) continues to be a major cause of death and disability worldwide.
This study assessed the effectiveness of non-invasive vagus nerve stimulation (nVNS) in …

A novel preclinical model of moderate primary blast-induced traumatic brain injury

AA Divani, AJ Murphy, J Meints… - Journal of …, 2015 - liebertpub.com
Blast-induced traumatic brain injury (bTBI) is the “signature” injury of the recent Iraq and
Afghanistan wars. Here, we present a novel method to induce bTBI using shock wave (SW) …

Neuroprotective pentapeptide, CN-105, improves outcomes in translational models of intracerebral hemorrhage

H Wang, TD Faw, Y Lin, S Huang, TN Venkatraman… - Neurocritical care, 2021 - Springer
Background Intracerebral hemorrhage (ICH) is a devastating form of cerebrovascular
disease for which there are no approved pharmacological interventions that improve …

An update on medical treatment for intracerebral hemorrhage

X Li, D Feng, G Chen - Translational Stroke Research, 2018 - Springer
Intracerebral hemorrhage (ICH), as a kind of hemorrhage stroke, is characterized by high
morbidity, mortality, and disability rates, which is a most serious disease in neurosurgery [1 …

Imidazoline receptor agonists for managing hypertension may hold promise for treatment of intracerebral hemorrhage

J Mahmoudi, A Majdi, S Lattanzi… - Current molecular …, 2018 - ingentaconnect.com
Intracerebral hemorrhage (ICH), which accounts for 10% of all strokes, leads to higher
morbidity and mortality compared with other stroke subtypes. Hypertension has been …

Inducing different brain injury levels using shock wave lithotripsy

AA Divani, P Salazar, M Monga… - … of Ultrasound in …, 2018 - Wiley Online Library
Objectives To assess the feasibility of inducing different severities of shock wave (SW)‐
induced traumatic brain injury (TBI) using lithotripsy. Methods Wistar rats (n= 36) were …